The mean FLC ratio of patients with CKD was 1.14 vs 0.63 in the controls (normal range 0.26 1.65). 14 (5%) of patients had abnormal FLC ratios suggesting abnormal or clonal sFLC production. SPE revealed that 7.6% of CKD patients had a monoclonal component confirmed by serum IFE as ...
In contrast, none of the 284 patients with CKD had an FLC κ/λ ratio exceeding the N Latex reference limits for healthy controls (0.31-1.56). The N Latex FLC κ/λ ratio in the CKD5 group (0.69, 0.32-1.54) was significantly lower compared with the control group (p<0.0001).These ...
Novel immunoassays have been developed which target the specific conformational, junctional epitopes between the heavy and light chains of the immunoglobulin making it possible to measure Ig'kappa and Ig'lambda and produce an Ig'kappa /Ig'lambda ratio. Here we describe the use of FLCr and heavy...
Kappa Free Light Chain Drift Prompts the Need for a New Upper Limit of Normal Free Light Chain Ratio to Avoid an Epidemic of Kappa Light Chain Monoclonal Gammopathy of Undermined Significance 2023, Journal of Applied Laboratory Medicine In response to: Defining new reference intervals for serum fr...
Validation of serum free light chain reference ranges in primary care. The demand for measurement of serum immunoglobulin free kappa (κ) and lambda (λ) light chains has increased. The κ:λ ratio is used to assist in diagnos... Luca,Galvani,Jane,... - 《Annals of Clinical Biochemistry》...
25.Tate J, Bazeley S, Klingberg S, Pretorius CJ, Hawley C, Mollee P. Comparison of the Freelite and N Latex serum free light chain (FLC) assays in chronic kidney disease [abstract]. Clin Biochem Rev 2012;33:S41.Search in Google Scholar ...
Define urine protein. urine protein synonyms, urine protein pronunciation, urine protein translation, English dictionary definition of urine protein. n. The waste product secreted by the kidneys that in mammals is a yellow to amber-colored, slightly acid
Although IC50s are dependent on the concentrations of the protein and ligand as well as the reaction Michaelis constant, under common assay conditions and reaction mechanisms (but not all), the ratio of the IC50s of two ligands is equivalent to the ratios of the Kis41. There is a ladder ...
足细胞是肾小球滤过屏障的重要组成部分,其数量减少或功能障碍将导致肾小球滤过功能损伤和相关肾脏疾病的发生。足细胞为不可再生性细胞,其数量和功能在一定程度上取决于其正常发育。已发表的文献和本实验室的研究工作表明,遗传或不良宫内环境等原因所致的足细胞发育不良,可能导致成年后肾小球滤过功能障碍,并成为某些胎...
Without inducing any additional carriers, the nanomedicine prepared by the resultant polymeric drugs possessed several excellent advantages: (1) The ratio of Pt(IV) and Int. J. Mol. Sci. 2018, 19, 2963 6 of 20 Int. J. Mol. Sci. 2018, 19, x FOR PEER REVIEW 6 of 19 DMC in ...