Biology definition: Aframeshift mutationis a type ofgene mutationin which the addition or deletion of one or morenucleotidescauses a shift in thereading frameof thecodonsin themRNA, which may lead to the altera
which is crucial for the prediction of the frame of the resulting frameshift peptides. As the translation of nucleotide into amino acid sequences is based on three base codons, every mutation in a homopolymer region can either result in a simple deletion or insertion of amino acids...
Nevertheless, even carrying the same mutation the age of the appearance of clinical symptoms can be very various [20]. One of the possible explanations of these facts is the differences in salvage mechanisms for persistence of fetal adrenal, which suggests that other factors, including epigenetics ...
SARS-CoV-2 has an FSE sequence identical to the original SARS-CoV-1 FSE up to a single-nucleotide substitution10(non-synonymous mutation C13533A). As with other coronavirus FSEs, the SARS-CoV-2 FSE has a 5′ heptanucleotide ‘slippery site’ UUUAAAC followed by an RNA element hypothesized...
FASTQ files were demultiplexed with NovoBarcode, and demultiplexed files were processed with ShapeMapper to obtain mutation strings for each read in a binary format. The simple_to_rdat.py script was used to generate 2D mutational profiles in RDAT files. These files were then analyzed with Biers...