Biology definition: Aframeshift mutationis a type ofgene mutationin which the addition or deletion of one or morenucleotidescauses a shift in thereading frameof thecodonsin themRNA, which may lead to the alteration in theamino acidsequence at proteintranslation.Variant:frame shift mutation.Synonyms...
which is crucial for the prediction of the frame of the resulting frameshift peptides. As the translation of nucleotide into amino acid sequences is based on three base codons, every mutation in a homopolymer region can either result in a simple deletion or insertion of amino acids...
Nevertheless, even carrying the same mutation the age of the appearance of clinical symptoms can be very various [20]. One of the possible explanations of these facts is the differences in salvage mechanisms for persistence of fetal adrenal, which suggests that other factors, including epigenetics ...