Whiteside SK et al. Acquisition of suppressive function by conventional T cells limits antitumor immunity upon Treg depletion. Sci Immunol. 2023 Dec 15;8(90):eabo5558.
调节性T细胞(Regulatory T cells,Tregs)是CD4+T细胞的一个重要分支,可通过抑制免疫功能参与维持自身免疫耐受,防止自身免疫疾病,也参与肿瘤细胞逃避机体免疫监视。FoxP3是调节性T细胞的关键转录因子,在调节性T细胞的发育和功能中发挥重要作用,F...
Peter Georgiev et al, Regulatory T Cells: the Many Faces of Foxp3, Journal of Clinical Immunology,https://doi.org/10.1007/s10875-019-00684-7 Charbonnier LM, Cui Y, Stephen-Victor E, Harb H, Lopez D, Bleesing JJ, et al. Functional reprogramming of regulatory T cells in the absence of...
2021年7月15日，来自美国洛克菲勒大学的Gabriel D. Victora团队在Science上在线发表题为“Expression of Foxp3 by T follicular helper cells in end-stage germinal centers”的文章，发现除了典型的TFR细胞外，还存在着第二群Foxp3 GC T细胞，它们在GC收缩前出现，通过上调Foxp3和TFH细胞有限地获得Treg样特征，证明...
Foxp3 转录因子流式固定破膜缓冲液经过配方设计和优化,可使用抗体对转录因子和核蛋白(例如 Foxp3 和 Ki-67)以及细胞因子和趋化因子进行染色。为了您的便利,我们已经提供了这些方案,用于在流式细胞仪上制备细胞内抗原检测用样品。已报告应用细胞内染色,然后进行流式细胞术分析了解更多信息 ...
Foxp3+ regulatory T cells: differentiation, specification, subphenotypes. Nat Immunol. 2009 Jul;10(7):689-95. doi: 10.1038/ni.1760. PMID: 19536194. [4]Kanamori M, Nakatsukasa H, Okada M, Lu Q, Yoshimura A. Induced Regulatory T Cells: Their Development, Stability, and Applications. ...
IPEX, FOXP3 and regulatory T-cells: a model for autoimmunity[J] . Hans D. Ochs,Eleonora Gambineri,Troy R. Torgerson.Immunologic Research . 2007 (1)Ochs HD, Gambineri E, Torgerson TR. IPEX, FOXP3 and regulatory T-cells: a model for autoimmunity. Immunologic research. 2007; 38:112-...
C.E.G.M. Pals, J. McCrae, S. Hemmers, V. Groenewold, H.-J. Vos, A. Rudensky, F. Pan, H. Li, D.M. Zaiss, P.J. Coffer, Nemo-like kinase drives Foxp3 stability and is critical for maintenance of immune tolerance by regulatory T cells, Cell Rep. 26 (2019) 3600–3612.e6 ...
Regulatory T (Treg) cells, which specifically express the master transcription factor FOXP3, have a pivotal role in maintaining immunological tolerance and homeostasis and have the potential to revolutionize cell therapies for autoimmune diseases1–3. Al
FOXP3 is a transcription factor that is essential for the development of regulatory T cells, a branch of T cells that suppress excessive inflammation and autoimmunity1,2,3,4,5. However, the molecular mechanisms of FOXP3 remain unclear. Here we here show that FOXP3 uses the forkhead domain—...