2. Bopp, T. et al. Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression. J. Exp. Med. 204, 1303–1310 (2007). 3. Stross, L. et al. Foxp3+ regulatory T cells protect the l...
8. Ribas, A. et al. Intratumoral immune cell infiltrates, FoxP3, and indoleamine 2,3-dioxygenase in patients with melanoma undergoing CTLA4 blockade. Clin. Cancer Res.15, 390–399 (2009).9. Edwards, J. et al. CD103+ tumor-resident CD8+ T cells are associated with improved survival in ...
CD8 regulatory T cellsinduction determinantssuppressive functioncytotoxic functionVarious mammalian CD8+T cell subsets with regulatory properties are either formed through a thymus-dependent mechanism or induced under various experimental protocols and referred to as CD8+regulatory T cells (Tregs). CD8+Tregs...
Transient rises inPD-1+Foxp3+ Treg and potentially anergic (CD57−KLRG1−PD-1+) cells in the circulating CD4 T cell compartment were paralleled by more profound increases in circulating CD8 T cells with traits of exhaustion (CD57−KLRG1+PD-1+,TIGIT+...
结论:CD8 + CD28 - Foxp3 + Tregs 在肝癌患者外周血及癌组织中增多,可能与肿瘤免疫抑制作用有关,其检测对肝癌患者病情有一定评估价值。 关键词 癌,肝细胞;T 淋巴细胞,调节性;叉头转录因子类 中图分类号:R735.7 Changes in CD8 + CD28 – Foxp3 + regulatory T cells in patients with hepatocellular ...
值得注意的是,HSD对肿瘤内CD4+FOXP3+调节性T细胞的频率没有影响。作者还观察到肿瘤内自然杀伤细胞数量略有增加,这与之前的一项研究一致。为了更好地了解饮食在肿瘤排斥过程中如何调节免疫系统,作者对接受NSD或HSD的小鼠(每组2只)分离出的CD45+细胞进行了单细胞RNA-seq(scRNA-seq)。聚类分析发现CD8+ T细胞(C4)、...
Transient rises inPD-1+Foxp3+ Treg and potentially anergic (CD57−KLRG1−PD-1+) cells in the circulating CD4 T cell compartment were paralleled by more profound increases in circulating CD8 T cells with traits of exhaustion (CD57−KLRG1+PD-1+,TIGIT+KLRG1+, and persistent down-modulation...
Human plasmacytoid dendritic cells induce CD8 LAG-3 Foxp3 CTLA-4 regulatory T cells that suppress allo- reactive memory T cells. Eur J Immunol 2011; 41:1663-74.Boor PP; Metselaar HJ; Jonge Sd;.Human plasmacytoid dendritic cells induce CD8 + LAG-3 + Foxp3 + CTLA-4 + regulatory T ...
Yeong J, Thike AA, Lim JC, et al. Higher densities of Foxp3+regulatory T cells are associated with better prognosis in triple-negative breast cancer. Breast Cancer Res Treat. 2017;163(1):21-35. Cecil DL, Slota M, O'Meara MM, et al. Immunization against HIF-1αinhibits the growth ...
为了确定 GPX4 在 CD8+ T 细胞介导的抗肿瘤反应中的作用,作者将 MC38 肿瘤细胞接种到对照组和 GPX4 cKO 宿主体内。与对照组小鼠相比,T细胞中 GPX4 的缺乏明显加速了肿瘤的生长(图 1I),并减轻了 CD8+ T 细胞的聚集(图 1J)和功能(图 1K),同时减少了总 CD4+ T 细胞和 CD4+Foxp3+ 调节性 T 细胞的...