Whiteside SK et al. Acquisition of suppressive function by conventional T cells limits antitumor immunity upon Treg depletion. Sci Immunol. 2023 Dec 15;8(90):eabo5558.
2021年7月15日，来自美国洛克菲勒大学的Gabriel D. Victora团队在Science上在线发表题为“Expression of Foxp3 by T follicular helper cells in end-stage germinal centers”的文章，发现除了典型的TFR细胞外，还存在着第二群Foxp3 GC T细胞，它们在GC收缩前出现，通过上调Foxp3和TFH细胞有限地获得Treg样特征，证明...
Figure 2.Localization, marker gene expression and DNA methylation status of exFoxp3 T cells in arthritic mice. Results are shown from fate mapping analyses of arthritic Foxp3-GFP-Cre × ROSA26-YFP mice that were performed 2 weeks after se...
Foxp3+ T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation. Mucosal Immunol. (2016) 9:444-57. doi: 10.1038/mi.2015.74Yang, B.H., Hagemann, S., Mamareli, P., Lauer, U., Hoffmann, U., Beckstette...
Figure 5.Pathogenic role of exFoxp3 T cells to arthritis in vivo. 三、场景再现 场景:关节炎 主人公:ex Foxp3 TH17细胞 我是ex Foxp3 TH17细胞,属于pTreg细胞部落,从CD25loFoxp3+ CD4+ T细胞丢失Foxp3表达,聚集到关节,经滑膜成纤维细胞产生的IL-6转变而来。表达Ccr6、CCL20、IL23R、RANKL是我的标志,...
Peter Georgiev et al, Regulatory T Cells: the Many Faces of Foxp3, Journal of Clinical Immunology,https://doi.org/10.1007/s10875-019-00684-7 Charbonnier LM, Cui Y, Stephen-Victor E, Harb H, Lopez D, Bleesing JJ, et al. Functional reprogramming of regulatory T cells in the absence of...
Peter Georgiev et al, Regulatory T Cells: the Many Faces of Foxp3, Journal of Clinical Immunology,https://doi.org/10.1007/s10875-019-00684-7 Charbonnier LM, Cui Y, Stephen-Victor E, Harb H, Lopez D, Bleesing JJ, et al. Functional reprogramming of regulatory T cells in the absence of...
FOXP3 is a transcription factor that is essential for the development of regulatory T cells, a branch of T cells that suppress excessive inflammation and autoimmunity1,2,3,4,5. However, the molecular mechanisms of FOXP3 remain unclear. Here we here show that FOXP3 uses the forkhead domain—...
C.E.G.M. Pals, J. McCrae, S. Hemmers, V. Groenewold, H.-J. Vos, A. Rudensky, F. Pan, H. Li, D.M. Zaiss, P.J. Coffer, Nemo-like kinase drives Foxp3 stability and is critical for maintenance of immune tolerance by regulatory T cells, Cell Rep. 26 (2019) 3600–3612.e6 ...
PD-L2 controls peripherally induced regulatory T cells by maintaining metabolic activity and Foxp3 stability,Nature Communications ,(2022) 13:5118