There are an increasing number of researches concerning the functions of Foxp3 in other cells, including lung epithelial cells besides Treg. However, the roles of Foxp3 in lung epithelial cells remain poorly understood. To examine the potential therapeutic benefits of Foxp3 for lung inflammation, ...
Breast cancer MDA-MB-231 cells were seeded in 24-well plates. Then, the cells were cotransfected with either vector control or FOXP3 (pcDNA3.1-FOXP3), pRL-Tk and VEGF promoter (pGL3-basic-VEGF) using Lipofectamine 3000. 36 h later, the cells were lysed in passive lysis buffer (Promeg...
Materials and Methods: For nuclear FOXP3 detection in epithelial breast cancer cells, tissue microarray technology was used. In addition, cultured breast cancer cell lines (ZR75-1, MCF7-WH, BT20, T47D, and SKBR3) were tested for FOXP3 expression using real-time polymerase chain reaction ...
Christodoulou MI, Moutsopoulos NM, Kapsogeorgou EK: OXP3 transcription factor is not confined to regulatory T (Treg) cells: Human epithelial cells express FOXP3 mRNA. Ann Rheum Dis. 2006, 65 (suppl 1): FA5- Google Scholar Zhang L, Zhao Y: The regulation of Foxp3 expression in regulat...
Christodoulou MI, Moutsopoulos NM, Kapsogeorgou EK: OXP3 transcription factor is not confined to regulatory T (Treg) cells: Human epithelial cells express FOXP3 mRNA. Ann Rheum Dis. 2006, 65 (suppl 1): FA5- Google Scholar Zhang L, Zhao Y: The regulation of Foxp3 expression in regulat...
Up⁃regulation of FOXP3 inhibits cell prolifer⁃ ation, migration and invasion in epithelial ovarian cancer [ J] . Cancer Lett, 2010,287(1) :91⁃97. [15] Takeuchi Y, Nishikawa H. Roles of regulatory T cells in cancer immunity[ J] . IntImmunol, 2016,28(8) :401⁃409. [16] ...
Retinal pigment epithelial cells induce foxp3(+) regulatory T cells via membrane-bound TGF-β Ocul Immunol Inflamm. 2010; 18 (6):459–469.Vega JL, Saban D, Carrier Y, et al. Retinal pigment epithelial cells induce foxp3(þ) regulatory T cells via membrane-bound TGF-beta. Ocul Immunol...
This study evaluated the expression of Foxp3 in non-small cell lung cancer (NSCLC) and investigated its role in epithelial‑mesenchymal transition (EMT) of cancer cells. qRT-PCR and western blot analysis were used for examining the expression of Foxp3 in NSCLC tissues and the non-tumor ...
FOXP3gene silencing inhibits epithelial -mesenchymal transformation and improves 5-fluorouracil resistance in lung adenocarcinoma LI Chun ，WANG Hefei ，HE Chengyuan ，FANG Hui ，PEI Yijie ，GAI Xiaodong.Department of Immunology ，School of Basic Medicine ，Beihua University ，Jilin 132013，China ［...
Notably, the NF-κB inhibitor bortezomib inhibited cell proliferation and induced apoptosis in prostate epithelial cells, attenuating prostatic intraepithelial neoplasia formation in Foxp3-mutant mice. Our data suggest that the FOXP3-miR-146-NF-κB axis has a functiona...