Whiteside SK et al. Acquisition of suppressive function by conventional T cells limits antitumor immunity upon Treg depletion. Sci Immunol. 2023 Dec 15;8(90):eabo5558.
Peter Georgiev et al, Regulatory T Cells: the Many Faces of Foxp3, Journal of Clinical Immunology,https://doi.org/10.1007/s10875-019-00684-7 Charbonnier LM, Cui Y, Stephen-Victor E, Harb H, Lopez D, Bleesing JJ, et al. Functional reprogramming of regulatory T cells in the absence of...
Owen DL, Mahmud SA, Sjaastad LE, Williams JB, Spanier JA, Simeonov DR, Ruscher R, Huang W, Proekt I, Miller CN et al (2019) Thymic regulatory T cells arise via two distinct developmental programs. Nat Immunol 20(2):195–205 Weiqi...
2021年7月15日，来自美国洛克菲勒大学的Gabriel D. Victora团队在Science上在线发表题为“Expression of Foxp3 by T follicular helper cells in end-stage germinal centers”的文章，发现除了典型的TFR细胞外，还存在着第二群Foxp3 GC T细胞，它们在GC收缩前出现，通过上调Foxp3和TFH细胞有限地获得Treg样特征，证明...
Peter Georgiev et al, Regulatory T Cells: the Many Faces of Foxp3, Journal of Clinical Immunology,https://doi.org/10.1007/s10875-019-00684-7 Charbonnier LM, Cui Y, Stephen-Victor E, Harb H, Lopez D, Bleesing JJ, et al. Functional reprogramming of regulatory T cells in the absence of...
C.E.G.M. Pals, J. McCrae, S. Hemmers, V. Groenewold, H.-J. Vos, A. Rudensky, F. Pan, H. Li, D.M. Zaiss, P.J. Coffer, Nemo-like kinase drives Foxp3 stability and is critical for maintenance of immune tolerance by regulatory T cells, Cell Rep. 26 (2019) 3600–3612.e6 ...
Foxp3+ regulatory T cells: differentiation, specification, subphenotypes. Nat Immunol. 2009 Jul;10(7):689-95. doi: 10.1038/ni.1760. PMID: 19536194. [4]Kanamori M, Nakatsukasa H, Okada M, Lu Q, Yoshimura A. Induced Regulatory T Cells: Their Development, Stability, and Applications. ...
T cells expressing FOXP3.Shuo, LiStuart, RobertsMagdalena, PlebanskiMaelenn, GouillouTim, SpelmanPhilippe, LatourDavid, JacksonLorena, BrownRosemary, L. SparrowH., Miles Prince
Figure 5.Pathogenic role of exFoxp3 T cells to arthritis in vivo. 三、场景再现 场景:关节炎 主人公:ex Foxp3 TH17细胞 我是ex Foxp3 TH17细胞,属于pTreg细胞部落,从CD25loFoxp3+ CD4+ T细胞丢失Foxp3表达,聚集到关节,经滑膜成纤维细胞产生的IL-6转变而来。表达Ccr6、CCL20、IL23R、RANKL是我的标志,...
KeyWords:regulatoryTcells;FOXP3:posttranslationalmodification FOXP3调节性T细胞(FOXP3+Tregs)属于T淋 巴细胞中表达CD4、CD25及转录因子FOXP3的一 类T细胞亚型,其正常功能对于人体免疫稳态 (immunehomeostasis)的动态调节必不可少⋯。调节 性T细胞的发育及功能失调,与多种重大免疫相关 ...