3. Dikiy, S. and Rudensky, A.Y. (2023) Principles of regulatory T cell function.Immunity56, 240-255. 10.1016/j.immuni.2023.01.004 4. Arvey, A.et al.(2014) Inflammation-induced repression of chromatin bound by the tr...
4. P. Gonzalez-Figueroa et al., Follicular regulatory T cells produce neuritin to regulate B cells. Cell184, 1775–1789.e19 (2021).
Foxp3+ regulatory T cells: differentiation, specification, subphenotypes. Nat Immunol. 2009 Jul;10(7):689-95. doi: 10.1038/ni.1760. PMID: 19536194. [4]Kanamori M, Nakatsukasa H, Okada M, Lu Q, Yoshimura A. Induced Regulatory T Cells: Their Development, Stability, and Applications. ...
Regulatory T cells (Treg) expressing the FOXP3 forkhead transcription factor maintain immunological self-tolerance and can enable tumour cells to escape immunosurveillance.To provide an overview of studies using FOXP3 as a biomarker in human malignancies, particularly in the context of the antibodies ...
Peter Georgiev et al, Regulatory T Cells: the Many Faces of Foxp3, Journal of Clinical Immunology,https://doi.org/10.1007/s10875-019-00684-7 Charbonnier LM, Cui Y, Stephen-Victor E, Harb H, Lopez D, Bleesing JJ, et al. Functional reprogramming of regulatory T cells in the absence of...
Regulatory T (Treg) cells expressing the transcription factor forkhead box P3 (Foxp3) play a requisite role in the maintenance of immunological homeostasis and prevention of peripheral self-tolerance breakdown. Although Foxp3 by itself is neither necessary nor sufficient to specify many aspects of the...
Sumida TS et al. The regulation and differentiation of regulatory T cells and their dysfunction in autoimmune diseases. Nat Rev Immunol. 2024 Feb 19. Vahl JC et al. Continuous T cell receptor signals maintain a functional regulatory T cell pool. Immunity. 2014...
Targeting tumor-infiltrating regulatory T cells (Tregs) is an efficient way to evoke an anti-tumor immune response. However, how Tregs maintain their fragility and stability remains largely unknown. IFITM3 and STAT1 are interferon-induced genes that play
Peter Georgiev et al, Regulatory T Cells: the Many Faces of Foxp3, Journal of Clinical Immunology,https://doi.org/10.1007/s10875-019-00684-7 Charbonnier LM, Cui Y, Stephen-Victor E, Harb H, Lopez D, Bleesing JJ, et al. Functional reprogramming of regulatory T cells in the absence of...
pTregs consist of other FoxP3− subsets: type 1 T regulatory (Tr1) cells and T helper 3 (Th3) cells, which have also been implicated in immune tolerance [18,34]. Unlike activated Tregs (CD4+CD45RA−CD25+FoxP3+), naïve Tregs (CD4+CD45RA+CD25−FoxP3+), exhibit a limited ...