调节性T细胞(regulatory T cells,Treg)是一类具有显著免疫抑制作用的,以表达Foxp3、CD25、CD4为细胞表型特征的T细胞亚群。它能够抑制其它细胞的免疫应答,是自我耐受的主要控制者。通常情况下,它的缺失或者功能异常会导致自身免疫性疾病的发生。免疫细胞在面对外来入侵的细菌、病毒等有害物质时,能够产生免疫应答反应识别...
4. P. Gonzalez-Figueroa et al., Follicular regulatory T cells produce neuritin to regulate B cells. Cell184, 1775–1789.e19 (2021).
Regulatory T cells (Treg) expressing the FOXP3 forkhead transcription factor maintain immunological self-tolerance and can enable tumour cells to escape immunosurveillance.To provide an overview of studies using FOXP3 as a biomarker in human malignancies, particularly in the context of the antibodies ...
参考资料 Peter Georgiev et al, Regulatory T Cells: the Many Faces of Foxp3, Journal of Clinical Immunology,https://doi.org/10.1007/s10875-019-00684-7 Charbonnier LM, Cui Y, Stephen-Victor E, Harb H, Lopez D, Bleesing JJ, et al. Functional reprogramming of regulatory T cells in the a...
Foxp3+ regulatory T cells: differentiation, specification, subphenotypes. Nat Immunol. 2009 Jul;10(7):689-95. doi: 10.1038/ni.1760. PMID: 19536194. [4]Kanamori M, Nakatsukasa H, Okada M, Lu Q, Yoshimura A. Induced Regulatory T Cells: Their Development, Stability, and Applications. ...
Owen DL, Mahmud SA, Sjaastad LE, Williams JB, Spanier JA, Simeonov DR, Ruscher R, Huang W, Proekt I, Miller CN et al (2019) Thymic regulatory T cells arise via two distinct developmental programs. Nat Immunol 20(2):195–205
Targeting tumor-infiltrating regulatory T cells (Tregs) is an efficient way to evoke an anti-tumor immune response. However, how Tregs maintain their fragility and stability remains largely unknown. IFITM3 and STAT1 are interferon-induced genes that play
Regulatory T cells (Tregs) play a fundamental role in maintaining immune homeostasis in vivo. Treg cells have been actively involved in controlling major human diseases including autoimmune diseases, infectious diseases, allergic diseases and the immune surveillance of tumors. The forkhead family transcrip...
Sumida TS et al. The regulation and differentiation of regulatory T cells and their dysfunction in autoimmune diseases. Nat Rev Immunol. 2024 Feb 19. Vahl JC et al. Continuous T cell receptor signals maintain a functional regulatory T cell pool. Immunity. 2014...
Peter Georgiev et al, Regulatory T Cells: the Many Faces of Foxp3, Journal of Clinical Immunology,https://doi.org/10.1007/s10875-019-00684-7 Charbonnier LM, Cui Y, Stephen-Victor E, Harb H, Lopez D, Bleesing JJ, et al. Functional reprogramming of regulatory T cells in the absence of...