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此外产生IL-17的Treg会有转录因子RORγt的表达。 本文转自ImmunoEra 考文献 Masahiro Ono,Control of regulatory T‐cell differentiation and function by T‐cell receptor signalling and Foxp3 tranion factor complexes, Immunology,2020, 160, 24–37 ...
Peter Georgiev et al, Regulatory T Cells: the Many Faces of Foxp3, Journal of Clinical Immunology,https://doi.org/10.1007/s10875-019-00684-7 Charbonnier LM, Cui Y, Stephen-Victor E, Harb H, Lopez D, Bleesing JJ, et al. Functional reprogramming of regulatory T cells in the absence of...
Foxp3+regulatory T cells are activated in spite of B7-CD28and CD40-CD40L blockade. Vogel I,Verbinnen B,Maes W,et al. European Journal of Immunology . 2013Vogel, I., Verbinnen, B., Maes, W., Boon, L., Van Gool, S. W. and Ceup- pens, J. L., Foxp3+ regulatory T cells are ...
KeyWords:regulatoryTcells;FOXP3:posttranslationalmodification FOXP3调节性T细胞(FOXP3+Tregs)属于T淋 巴细胞中表达CD4、CD25及转录因子FOXP3的一 类T细胞亚型,其正常功能对于人体免疫稳态 (immunehomeostasis)的动态调节必不可少⋯。调节 性T细胞的发育及功能失调,与多种重大免疫相关 ...
调节性T细胞(regulatory T,Treg)是一类控制体内免疫反应性的T细胞亚群,根据来源的不同,Treg 细胞可分为自然性Treg (natural Treg, nTreg) 和诱导性 Treg(induced Treg, iTreg)。 nTreg由胸腺分化而来,占外周血CD4+ T细胞的5%~10%,这类细胞本身缺乏增殖能力,但具有天然免疫抑制作用,不仅可抑制CD4+或CD8+ T细胞...
Foxp3+ regulatory T cells: differentiation, specification, subphenotypes. Nat Immunol. 2009 Jul;10(7):689-95. doi: 10.1038/ni.1760. PMID: 19536194. [4]Kanamori M, Nakatsukasa H, Okada M, Lu Q, Yoshimura A. Induced Regulatory T Cells: Their Development, Stability, and Applications. ...