调节性T细胞(regulatory T cells,Treg)是一类具有显著免疫抑制作用的,以表达Foxp3、CD25、CD4为细胞表型特征的T细胞亚群。它能够抑制其它细胞的免疫应答,是自我耐受的主要控制者。通常情况下,它的缺失或者功能异常会导致自身免疫性疾病的发生。免疫细胞在面对外来入侵的细菌、病毒等有害物质时,能够产生免疫应答反应识别...
Peter Georgiev et al, Regulatory T Cells: the Many Faces of Foxp3, Journal of Clinical Immunology,https://doi.org/10.1007/s10875-019-00684-7 Charbonnier LM, Cui Y, Stephen-Victor E, Harb H, Lopez D, Bleesing JJ, et al. Functional reprogramming of regulatory T cells in the absence of...
2021年7月15日，来自美国洛克菲勒大学的Gabriel D. Victora团队在Science上在线发表题为“Expression of Foxp3 by T follicular helper cells in end-stage germinal centers”的文章，发现除了典型的TFR细胞外，还存在着第二群Foxp3 GC T细胞，它们在GC收缩前出现，通过上调Foxp3和TFH细胞有限地获得Treg样特征，证明...
Regulatory T cells (Treg) expressing the FOXP3 forkhead transcription factor maintain immunological self-tolerance and can enable tumour cells to escape immunosurveillance.To provide an overview of studies using FOXP3 as a biomarker in human malignancies, particularly in the context of the antibodies ...
Foxp3+ regulatory T cells: differentiation, specification, subphenotypes. Nat Immunol. 2009 Jul;10(7):689-95. doi: 10.1038/ni.1760. PMID: 19536194. [4]Kanamori M, Nakatsukasa H, Okada M, Lu Q, Yoshimura A. Induced Regulatory T Cells: Their Development, Stability, and Applications. ...
FOXP3+ regulatory T (Treg) cells are critical in maintaining immune tolerance and homeostasis of the immune system. The molecular mechanisms underlying the stability, plasticity and functional activity of Treg cells have been much studied in recent years
Peter Georgiev et al, Regulatory T Cells: the Many Faces of Foxp3, Journal of Clinical Immunology,https://doi.org/10.1007/s10875-019-00684-7 Charbonnier LM, Cui Y, Stephen-Victor E, Harb H, Lopez D, Bleesing JJ, et al. Functional reprogramming of regulatory T cells in the absence of...
It has been therefore suggested that a dysfunction of regulatory T cells, the orchestrators of immune homeostasis, could be implicated in perpetuating T cell activation in this condition. However, the actual contribution of regulatory T cell dysfunction in the immunopathogenesis of primary minimal ...
而如果在炎症环境中维持Treg功能的因子(如IL-2)缺失或者不足时,Treg会变得不稳定,Treg中的Th特征性转录因子会赋予Treg促炎功能(box1)。 Nat Rev Immunol. 2024 Feb 19. 参考资料 Sumida TS et al. The regulation and differentiation of regulatory T cells and their dysfu...
Targeting tumor-infiltrating regulatory T cells (Tregs) is an efficient way to evoke an anti-tumor immune response. However, how Tregs maintain their fragility and stability remains largely unknown. IFITM3 and STAT1 are interferon-induced genes that play