The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in kera...
flgAstrocytic tumorTumor progressionflg is a high-affinity receptor of basic fibroblast growth factor (bFGF) and a transmembrane protein that activates tyrosine kinase. The flg gene, as well as bFGF, expresses highly in astrocytic tumors. We investigated changes of bFGF and flg gene expression ...
(FLG),which encodes prof ilaggrin,is located on human chromosomelq21.3. FLG is associated with the epidermal barrier and the cell differentiation.The polymorphism of FLG gene is closely associated with atopic dermatitis,psoriasis,ichthyosis vulgaris as well as other diseases.The FLG gene and related...
【摘要】丝聚蛋白(filaggrin,FLG)基因位于人类染色体1q21.3,其翻译表达产物与维持皮肤屏障和细胞分化功能密切相关.研究发现FLG基因的多态性与特应性皮炎、银屑病、寻常型鱼鳞病等多种疾病发病相关,本文对近年关于FLG基因及与其相关疾病的研究进行了综述.%Filaggrin gene (FLG), which encodes profilaggrin, is located...
gene and related diseases were reviewed in this article．［Key words］FLG；atopic dermatitis；psoriasis；ichthyosis vulgaris 中间丝蛋白相关基因（Filaggrin，FLG）的翻译表达产物Profilaggrin是存在于人表皮角质形成细胞（keratinocyte，KC）内的一种酸性或中性蛋白，参与角质形成细胞终末分化时细胞间交叉联结膜的形成，...
关键词:特应性皮炎;丝聚蛋白基因;多态性中图分类号:R758.2 文献标识码:A 文章编号:1672⁃3619(2017)07⁃0904⁃04Polymorphism in the filaggrin gene in Guangdong Han population with atopicdermatitisTIAN Xin 1 ,PENG Xing 2 ,ZHOU Xin 1 ,YANG Yan 1 ,LIU Yu⁃mei 1( 1.Guangzhou Institute of...
它最初被合成为一种多蛋白前体profilaggrin(由324a a的多个filaggrin单元组成),定位于角质透明蛋白颗粒中,随后被蛋白质水解成单个功能性filaggrin分子。该基因突变与寻常性鱼鳞病有关。[由RefSeq提供,2009年12月]The protein encoded by this gene is an intermediate filament-associated protein that aggregates ...
Mutations in filaggrin gene (FLG) are found to be most strongly associated with AD genetically. Previous studies represent that one of the most common mutations, K4671X is specific in Chinese Han population. The mutation carriers in either AD or ichthyosis vulgaris is significantly more than that...
梅奥诊所推出一款名为“梅奥诊所基因指南(Mayo Clinic GeneGuide)”的基因检测和用户教育APP,宣布进入消费级基因检测市场。在梅奥诊所的网站上,这款新的APP被称为“可以帮助您了解遗传如何影响您健康的一项基因检测”。该APP服务也可通过Helix平台获得。 梅奥诊所进军消费级基因检测市场 Read More »ADx Healthcare, ...
保存条件 12 months from date of receipt,-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. 背景资料 In humans,profillagrin is encoded by the FLG gene,which is part of the S100 fused-type protein (SFTP) family within the epidermal differentiation com...