Mutations in filaggrin gene (FLG) are found to be most strongly associated with AD genetically. Previous studies represent that one of the most common mutations, K4671X is specific in Chinese Han population. The mutation carriers in either AD or ichthyosis vulgaris is significantly more than that...
We found that patients with severe AE were less likely to have a history of AV only if they had an existing FLG LoF mutation (P = 0.02). CONCLUSIONS. In the context of AE, our work suggests that FLG LoF mutations protect patients from developing AV.Hughes Aaron J...
Results: Analysis of base sequence previously unreported reveal new nonsense mutation p.Y1767X in a Korean IV patient, and additional new single nucleotide polymorphisms. Conclusion: On the basis of this study, it is anticipated that analysis of FLG gene sequence be extended to other dermatoses ...
In Copenhagen, FLG mutation increased the risk of eczema in infants. Infantile eczema linked to cat ownership in children with gene mutation Two loss-of-function mutations of FLG, RS01X and 2282de14, now have been shown to be responsible for a lack of filaggrin in the upper epidermis among...
日本化粧品技術者会誌糖化に起因する表皮機能低下に対するワイルドタイムエキスの防御効果 J DermatolFilaggrin‐gene mutation has minimal effect on the disease severity in the lesions of atopic dermatitis34322929
上海交通大学 博士学位论文 FLG基因功能缺失突变及其疾病相关性研究 姓名:***申请学位级别:博士 专业:皮肤病与性病学 指导教师:**荣 201205 上海交通大学博士学位论文 FLG基因功能缺失突变及其疾病相关性研究 摘要 目的:分析中间丝相关蛋白基I因(Filaggrin,FLG)功能缺失突变与特应性 皮炎(atopicdermatitis,AD)和单纯...
9 RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook FLG Medical Acronyms FLG On drawings, abbr. forflooring. McGraw-Hill Dictionary of Architecture and Construction. Copyright © 2003 by McGraw-Hill Companies, Inc. ...
N/TERT-2G keratinocytes were electroporated with RNP complex containing FLG-specific gRNA and synthetic SpCas9 protein, introducing NHEJ-induced insertions and deletions leading to a frameshift mutation. (b) FLG gene was analyzed after PCR amplification of the knockout locus (reverse complement ...
When introduced by bombardment into Arabidopsis cells the ERF4-R coding region reduced the expression of the reporter gene .2-fold, whereas expression of the ERF4-A coding region activated the expression of the reporter gene .7-fold (Fig. 4A). These data indicate that deletion of the EAR ...
Alternative mRNA splicing can result in a diversity of functional proteins by a single gene. Stress responsive genes are particularly prone to be alternatively spliced in plants32. For instance, alternative splicing of Toll-like resistance genes play a crucial role in immunity pathways33. A splicing...