Background When the dense fine speckled (DFS) pattern-antinuclear antibodies (ANA) are detected in the indirect immunofluorescence (IIF) assay, the presence of anti-dense fine speckles 70 (DFS70) antibodies has been suggested to facilitate the exclusion of ANA-associated rheumatic diseases (AARD)....
Importance of the dense fine speckled pattern on HEp-2 cells and anti-DFS70 antibodies for the diagnosis of systemic autoimmune diseases The presence of anti-nuclear antibodies (ANA) is a hallmark of systemic autoimmune rheumatic diseases (SARD). The indirect immunofluorescence (IIF) assay o... ...
Certain IIF patterns have known antibody and disease associations, but the dense fine speckled (ANA-DFS) pattern has no confirmed clinical associations. Our objective was to determine the prevalence of SARD among a group of ANA-DFS positive individuals and to identify final diagnoses among non-...
Audit of dense fine speckled ana patterns detected by indirect immunofluorescence in a clinical immunology laboratorydoi:10.1016/j.pathol.2016.12.333Wade, LucyAcquarola, NickHall, AnneSjollema, PaulO’Sullivan, MichaelElsevier B.V.Pathology
Nuclear dense fine speckled (DFS) pattern, a competent-level pattern evaluated by the ICAP previously (AC-02),2 is frequently discussed in the current recommendation for it being the pattern best associated with apparently healthy individuals, or negatively correlating with systemic autoimmune rheumatic...
In particular, autoantibodies associated with the dense fine speckled (DSF) ANA-Hep-2 pattern, has been largely detected in apparently healthy individuals. Methods ANA-Hep-2 test from 921 children aged 0.2 to 13.9 years was retrospectively retrieved from the routine of a large private laboratory ...
Background The nuclear dense fine speckled (DFS) pattern is one of the most commonly observed finding in indirect immunofluorescence-antinuclear antibody (IIF-ANA) assay on HEp-2 cells. Unlike other ANA, DFS pattern is not prevalent in ANA-associated rheumatic diseases (AARD). The antigen was ...
2007. Relevance of the immunofluorescence pattern for interpretation of the ANA test: the case of the dense fine speckled pattern. Rev Assoc Med Brasil 53: 439-445.Dellavance A; Leser PG,Andrade LE; Relevance of the immunofluorescence pattern for interpre tation of the ANA test-the case of ...
In the analysis of specific autoantibodies, more than half of the samples with an AC-2 pattern (54.2%) had specific autoantibodies other than anti-DFS70. We conclude that the flowchart for discriminating between AC-1 and AC-2 ANA patterns in this study is a via...
ANA patterns in the experimental dataset: (a) coarse speckled (b) fine speckled (c) nucleolar (d) peripheral.Jiaqian, LiKuoKun, TsengZu, Yi HsiehChing, Wen YangHuangNan, Huang