(5) 着丝点型(centromerepattern) 又称散在斑点型(discretespeckledpattern)。分裂间期细胞核内均匀散布大小较一致的着染荧光细颗粒(40〜60个),无核膜结构,分裂期细胞染色质着丝点密集排列。如分裂期细胞呈典型阳性荧光染色,即可判断抗着丝点抗体阳性。(6) 胞质型(cytoplasmicpattern) 分裂间期细胞胞质突光染色阳...
1. **均质型（homegeneouspattern, H）**：分裂间期细胞核质染色均匀一致，分裂期细胞染色质阳性。与抗DNP抗体、抗dsDNA抗体、抗组蛋白抗体和抗核小体抗体相关。2. **斑点型（speckledpattern, S）**：分裂间期细胞核质染色呈斑点状、斑块状，核仁阴性；分裂期细胞染色质阴性。常见于抗可溶性核抗原(EN...
Speckled: Fine and coarse speckles of ANA staining are seen throughout the nucleus. This pattern is more commonly associated with antibodies to extractable nuclear antigens. This pattern can be associated with Systemic Lupus Erythematosus, Sjögren’s syndrome, Systemic Sclerosis, Polymyositis, and Rh...
(2 )斑点型(speckled pattern , S ):又称颗粒型,核斑块型。核质染色呈斑点状.斑块状,核仁阴性,中期细胞染色质阴性。此荧光染色模型与可溶性抗原(ENA)抗体有关。 (3 )核仁型(nucleolar pattern , N ):核仁着染荧光,中性细胞染色质阴性。核仁颗粒型,常与抗U 3nRNP/Fibrillarin抗体、抗RNA多聚酶I抗体相关;仁...
2.斑点型(speckled pattern,S):又称核颗粒型、核斑块型。和细胞核可溶性核蛋白物质ENA,其相关疾病为硬皮病(SSc)、干燥综合征(SS)、多发性肌炎/皮肤炎(PM/DM)、系统性红斑狼疮(SLE)、类风湿关节炎(RA)等。3.核仁型(nuclear pattern,N):核仁颗粒型常与抗U3nRNP/Fibrillarin抗体、抗RNA多聚酶I抗体相关;核仁...
The antinuclear antibody (ANA) test has high sensitivity in diagnosing and classifying systemic lupus erythematosus (SLE).#To describe the immunological pattern of SLE patients through investigating specific antinuclear autoantibodies by enzyme dot immunoassay and studying their frequency in both positive ...
Can you have speckled and homogeneous ANA? The presence of ANA with a homogeneous & speckled (HS) pattern was significantly associated with the absence of cancer (p < 0.01). Patients with a HS pattern were found to have a lower relative risk (RR 0.7, 95%CI 0.5-0.9) of having cancer ...
The “true Speckled” antinuclear antibody (ANA) pattern: Its tumultuous history☆Author links open overlay panelThomas K. Burnham 1, D'Anne M. Kleinsmith 1Show more Add to Mendeley Share Cite https://doi.org/10.1016/0049-0172(83)90001-XGet rights and contentAccess through your organization ...
When a positive ANA result is obtained on HEp-2 cells, further studies are necessary to identify the specific autoantibodies responsible of the IIF pattern, such as anti-dsDNA or anti-ENA antibodies. While a positive result on these second-step assays could point towards a possible SARD, a ...
Speckled:Speckled fluorescence due to an antibody directed against different nuclear antigens. This pattern is common in lupus and other connective tissue diseases, such asSjogren's syndrome. Nucleolar:Formed from antibodies directed against specific proteins involved in the maturation of RNA. Seen in ...