Audit of dense fine speckled ana patterns detected by indirect immunofluorescence in a clinical immunology laboratorydoi:10.1016/j.pathol.2016.12.333Wade, LucyAcquarola, NickHall, AnneSjollema, PaulO’Sullivan, MichaelElsevier B.V.Pathology
This distinction is not only based on the fact that the pattern is easily recognizable, but also on its clinical relevance [17]. According to ICAP, the following AC patterns are competent-level: nuclear homogenous, speckled, dense fine speckled (DFS), centromere, nucleolar and discrete dots ...
Background/Purpose: A Mixed Speckled/Homogeneous(MS/H) pattern is the single most common ANA pattern identified in our community hospital patient population, often in very high titers, and has been associated with a “Dense Fine Speckled” anti-DFS70 ENA specificity. ...
(A) Dense fine speckled pattern of the interphase nuclei (1) as well as of the metaphase chromatin (2) of a DFS70 antibody; (B) classic homogeneous ANA pattern of a dsDNA antibody with homogeneous-peripheral staining of the interphase nuclei (1) as well as of the chromatin in all mitoti...
Monospecific anti-DFS70 antibodies are moderately helpful in excluding ANA-associated rheumatic disease in patients presenting with a dense fine speckled p... CF Cheng,T Lan,M Shih,... - 《Autoimmunity Reviews》 被引量: 0发表: 2020年 Antineutrophil cytoplasmic autoantibody-associated alveolar ...
The clinical spectrum of antinuclear antibodies associated with the nuclear dense fine speckled immunofluorescence pattern. J Rheumatol 2005;32,2144–49. Mahler M, Hanly JG, Fritzler MJ. Importance of the dense fine speckled pattern on HEp-2 cells and anti-DFS70 antibodies for the diagnosis of ...
2007. Relevance of the immunofluorescence pattern for interpretation of the ANA test: the case of the dense fine speckled pattern. Rev Assoc Med Brasil 53: 439-445.Dellavance A; Leser PG,Andrade LE; Relevance of the immunofluorescence pattern for interpre tation of the ANA test-the case of ...
Except for dense fine speckled (DFS), the nuclear competent patterns were reported by >85% of the laboratories. Except for rods and rings, the cytoplasmic competent patterns were reported by >72% of laboratories. Cytoplasmic IIF staining was considered ANA positive by 55% of clinicians and 62%...
Research results on the relevance of the dense fine speckled (DFS) pattern and DFS70 antibodies disclosed novel possibilities to optimize the serological stepwise diagnostics of AARD. The DFS pattern on HEp-2 cells is well differentiated from the classic "homogeneous" A...
Up to 20% of serum samples from HI have been reported to have a positive ANA IIF test, the majority of them due to the presence of anti-dense fine speckled 70 (anti-DFS70) antibodies. Monospecific anti-DFS70 antibodies represent a biomarker that can be used to discriminate AARD patients...