The trial was conducted in two stages, using the optimal two-stage design described by Simon [23]. The hypothesis was that a histological response rate of 30 % does not warrant further investigation of the regimen, and a response rate of 60 % would lead to the conclusion that the regimen...
The largest of these classes comprises the PIWI- interacting RNAs (piRNAs), whose expression is limited to specific developmental stages of germ cells [7]. The remaining categories are more widely expressed and include the ~22 nucleotides long microRNAs (miRNAs) [8], the longer than 200 ...