Aldape, Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell 9, 157–173 (2006) Article CAS PubMed Google Scholar R.G.W. Verhaak, K.A. Hoadley, E. Purdom, V. Wang, Y. Qi, M.D. ...
Glioblastoma (GB) is a highly invasive type of brain cancer exhibiting poor prognosis. As such, its microenvironment plays a crucial role in its progression. Among the brain stromal cells, the microglia were shown to facilitate GB invasion and immunosuppression. However, the reciprocal mechanisms by...
Methods: We re-analyzed the single-cell profiles of GBM from patients with different subtypes by single-cell transcriptomic analysis and further subdivided the large population of Glioma cells into different subpopulations, explored the interrelationships and active pathways among cell...
75, 76 In the early stages of tumorigenesis, it would limit cell proliferation, DNA damage and therefore tumor progression. When the tumor size increases, its blood supply is restricted, and autophagy may promote the survival of tumor cells in the nutrient-deficient and hypoxic tumor regions.77...
By using the MEK-inhibitor PD98059, we observed an increased KRAS protein expression and the concomitant ERK dephosphorylation exerting opposite effect on percentage of apoptotic cells and, doing so, blocked the progression at various stages of the cell cycle. The MEK/ERK pathway is considered to ...
(black) myeloid cells. Scale bar: 50 µm. Sections were co-stained with hematoxylin. See more examples in Additional file2: Fig S1B.BRepresentative Iba1 staining representing myeloid cells in PDOX P3 at different stages of tumor growth. Inserts represent sections of the entire mouse brains....
Methods: We re-analyzed the single-cell profiles of GBM from patients with different subtypes by single-cell transcriptomic analysis and further subdivided the large population of Glioma cells into different subpopulations, explored the interrelationships and active pathways among cell stages and clinical ...
A major contributing factor to glioblastoma (GBM) development and progression is its ability to evade the immune system by creating an immune-suppressive environment, where GBM-associated myeloid cells, including resident microglia and peripheral monocyt
et al. Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell 9, 157–173 (2006). This was one of the first studies to classify GBM into three distinct molecular subclasses on the basis of gene ...
S. et al. Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell 9, 157–173 (2006). Article CAS PubMed Google Scholar Huang, H. S. et al. The enhanced tumorigenic activity of a mutant ...