The trial was conducted in two stages, using the optimal two-stage design described by Simon [23]. The hypothesis was that a histological response rate of 30 % does not warrant further investigation of the regimen, and a response rate of 60 % would lead to the conclusion that the regimen...
In October 2016 Downie played two live shows with hisSecret Pathcollaborators to promote the album. He recorded three more solo albums before his death a year later. On the morning of Downie’s death, Trudeau addressed the media. Visibly shaken, the prme minister, who had grown up during th...