Lidia Gil-Martínez, Isabel Casado-Fariñas, Jorge Bartolomé, Pedro Pérez-Segura, Durable benefit and slowdown in tumor growth dynamics with erdafitinib in a FGFR3-TACC3 fusion-positive IDH-wild type glioblastoma, Neuro-Oncology Advances, 2024;, vdae139, https://doi.org/10.1093/noajnl...
参考文献: Bae, H.; Lee, B.; Hwang, S.; Lee, J.; Kim, H.-S.; Suh, Y.-L. Clinicopathological and Molecular Characteristics of IDH-Wildtype Glioblastoma with FGFR3::TACC3 Fusion. Biomedicines 2024, 12, 150.https://doi.org/10.3390/biomedicines12010150...
都发现了F3–T3 fusion gene correlated with mitochondrial activities 然后又用了 regularized gradient boosting machine 算法来检测FGFR3-TACC3基因融合造成的基因表达变化模式相关的转录因子,发现跟 PPARGC1A and ESRRG 类似。 而且有FGFR3-TACC3基因融合现象的样本里面的 PPARGC1A and ESRRG 表达量的确增高了。
Targeted therapy with anlotinib for a patient with an oncogenic FGFR3–TACC3 fusion and recurrent glioblastoma 推荐阅读 cfDNA分子改变在结直肠癌诊断、治疗、预后等方面带来的提示 罕见病例|一例组织学从肺腺癌转变为小细胞肺癌的病...
FormatRNA DescriptionFGFR3-TACC3 results from the fusion of FGFR3 and TACC3, demonstrating constitutive kinase activity, transforming activity in culture and ability to drive tumor growth in xenografts (PMID: 25294908, PMID: 22837387). FGFR3-TACC3 has been identified in lung adenocarcinoma and glio...
We herein present a case of recurrent GBMs, IDH wt, exhibiting some of the above-mentioned morphological features and a molecularly-proven FGFR3-TACC3 fusion. A 56-year-old man presented to our hospital for a recurrent GBM, IDH wt, surgically treated at another cen...
FGFR3 Fusion R248C Y373C G370C FGFR3-BAIAP2L1 G691R FUSION VARIANTS V443L V443M V496V V555M G380R F386L K650E EXPRESSION MUTATION FGFR3 基因突变 FGFR3-TACC3 Allele Registry ID:别名: ClinVar ID: 基因突变位点 Ref. Build: Ensembl Version: null Chr. Start Stop Ref. s Var. Bases...
Pascale Varlet1,2, Dominique Figarella‑Branger3,4* and The Biopathology RENOCLIP-LOC network Abstract Background Gliomas with FGFR3::TACC3 fusion mainly occur in adults, display pathological features of glioblastomas (GB) and are usually classified as glioblastoma, IDH-wildty...
FGFR3-TACC3 results from the fusion of FGFR3 and TACC3, demonstrating constitutive kinase activity, transforming activity in culture and ability to drive tumor growth in xenografts (PMID: 25294908, PMID: 22837387). FGFR3-TACC3 has been identified in lung adenocarcinoma and glioblastoma (PMID: 252...
Here we show that human basal stem cells (BSCs) isolated from heavy smokers proliferate extensively, whereas their alveolar...doi:10.1038/s41388-018-0399-5Best Sarah A.Harapas Cassandra R.Kersbergen ArienaRathi VivekAsselin-Labat Marie-LiesseSutherland Kate D.Oncogene...