After subcutaneous injection of primary human T-ALL cells with MSCs, tumour growth was suppressed when FGF2/FGFR2 was interrupted. Thus, inhibition of FGF2/FGFR2 interaction appears to be a valid strategy to overcome BM-MSCs mediated progression of T-ALL, and BGJ398 could indeed improve ...
The FGF interaction with the four canonical FGFR leads to a series of receptor conformational changes culminating with the activation of intracellular signaling cascades (Fig.4). The first step is the transphosphorylation of the tyrosine kinase (TK) domain that induces receptor dimerization and phospho...
The FGF interaction with the four canonical FGFR leads to a series of receptor conformational changes culminating with the activation of intracellular signaling cascades (Fig.4). The first step is the transphosphorylation of the tyrosine kinase (TK) domain that induces receptor dimerization and phospho...
ECM-related physical interaction might be a regulator of angiogenic potential. When endothelial cells reside in a complex 3D architecture, they perceive cues from the ECM through cell-cell or chemo-mechanical coupling, and finally generate angiogenic responses35. In the present study, both cell ...
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Interaction of Fibroblast Growth Factor-2 (FGF-2) with Free Gangliosides: Biochemical Characterization and Biological Consequences in Endothelial Cell Cult... Exogenous gangliosides affect the angiogenic activity of fibroblast growth factor-2 (FGF-2), but their mechanism of action has not been elucida...
Anterior expression was also altered with FGFR1 expression being lost, whereas FGFR4 expression was expanded beyond its normal expression domain. RARalpha2 is required for the expression of XCAD3 and HOXB9, and for the ability of XCAD3 to induce HOXB9 expression. We conclude that RARalpha2 is...
However, we could not detect a direct binding of FGF-1 and -2 with Hsp90 in in vitro studies4 . However, if Hsp90 acts as a molecular ratchet similar to Bip in ER translocation, we should possibly not be able to see a stable interaction, since in this case, they only interact ...
Macrophages express FGF receptors following interaction with tumour cells Since an immune response was required for tumour regression inFgf2LMW−/−mice, we asked which immune cells expressed FGF2 receptors. Despite the involvement of T cells in tumour regression, we failed to detect FGFR1 or ...