However, many of the biological activities of FGF-2 have been found to depend on its receptor's intrinsic tyrosine kinase activity and second messengers such as the mitogen activated protein kinases. This review will focus on the mechanism of FGF-2/FGFR induced signaling pathway in tumor and ...
FGFR2及其配体基因变异对钛与乳腺癌风险关联的修饰作用 目的钛具有抗癌作用,但可能受个体遗传素质影响。本研究拟探讨成纤维细胞生长因子受体2(Fibroblast Growth Factor Receptor 2,FGFR2)及其配体:FGF 1多态性位点对尿钛与乳腺癌风险关联的修饰作用。方法采用病例对照研究设计。在2009年10月至2010年7月间,对新... ...
Therefore, it seems that in the SVZ FGF-2 may be released by GFAP-positive cells, different from the precursor cell lineage, and via volume transmission it reaches the proliferating precursor cells. FGFR-1 mRNA is also expressed in the SGZ and is localized in BrdU-labeled precursor cells, ...
FGF2蛋白在NSCLC肺组织中的表达水平与患者年龄,性别,吸烟史,组织学 类型无相关性;在有无淋巴结转移中存在明显差异(P=0.013),在临床分期不 同的表达中存在明显的差异(P=0.03),FGF2蛋白的表达水平与淋巴结转移和 临床分期呈正相关。 (2)FGFR2bmRNA在非小细胞肺癌中的表达明显低于癌旁正常组织 ...
关键字: FGF R2 (IIIc);FGF R2 (IIIc)蛋白;FGFR2;ACRO;百普赛斯; 公司简介 百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲...
检测不同浓度FGF-2作用下牙髓细胞OPN mRNA的表达.结果:与对照组相比,FGF-2在1～50 ng/mL浓度下均可促进牙髓细胞FGFR的表达(P〈0.05),最佳显效浓度为10 ng/mL.FGF-2在1～50 ng/mL浓度下均可诱导牙髓细胞OPN mRNA表达(P〈0.05),OPN mRNA的表达在10 ng/mL的FGF-2作用下达到高峰.结论:FGF-2可促进体外...
Interactions between FGF10 and the IIIb isoform of FGFR-2 appear to be crucial for the induction and growth of several organs, particularly those that involve budding morphogenesis. We determined their expression patterns in the inner ear and analyzed the inner ear phenotype of mice specifically del...
In both Fgf10 and Fgfr2 deficient mutant hypospadic male mice, cell proliferation is arrested prematurely and the maturation of the urethral epithelium is disrupted. Fgf8, Fgf10, and their receptor Fgfr2 are downstream targets of androgens (AR) during external genital development, an important ...
目的:FGFR信号通路异常在中国人群结直肠癌中的比例接近30%,FGFR信号通路异常与结直肠癌发生发展及预后不良相关,课题组前期初步分析发现PAI-1表达可能与FGFR信号通路相关.本研究旨在进一步探索FGF/FGFR2信号通路对结肠癌PAI-1表达的调控机制,并探索PAI-1对结肠癌免疫微环境的影响. 方法:(1)通过TCGA和GEO数据库(GSE164...
FGFR2, FGF8, FGF10 and BMP7 as candidate genes for hypospadias. Hypospadias is a common malformation, which results from failure of urethral tube closure, and whose molecular mechanisms are still largely unknown. The no... A Beleza-Meireles,F Lundberg,K Lagerstedt,... - 《European Journal ...