(成年成纤维细胞和胎儿成纤维细胞)的出生死亡克隆牛的6个组织(心脏,肝脏,脾脏,肺脏,肾脏和大脑)中的表达.结果表明:FGFR1的表达在来自两种供体细胞的体细胞克隆牛的心脏(P<0.05)和肝脏(P<0.05)显著升高,FGF2基因在体细胞克隆牛组织中的表达未发现异常.由于FGFR1在胚胎发育和器官形成中起重要作用,所以FGFR1的异常...
FGFR1基因所编码的蛋白质是属于成纤维细胞生长因子受体(FGFR)家族成员之一,目前已确定了四种由FGFRs, 即FGFR1、FGFR2、FGFR3和FGFR4。FGFR1是一种跨膜蛋白质,属于受体酪氨酸激酶,当FGF与FGFR1胞外段结合后,受体细胞内段酪氨酸激酶活性区首先发生自身磷酸化,然后使受体靶蛋白发生反式磷酸化,通过蛋白质级联反应将配体...
Pharmacological inhibition and siRNA knockdown of FGFR1 induced apoptosis in lung SCC cells. Our in vivo study indicated that honokiol could suppress the growth of xenograft tumors, and this effect was associated with the inhibition of the FGF2-FGFR1 signaling pathway. In conclusion, honokiol induced...
目的:探讨缬沙坦对单侧榆尿管梗阻(UUO)大鼠肾组织Klotho蛋白、FGF2/FGFR1信号通路表达的影响.方法:将Wistar雄性大鼠随机分为3组:对照组、UUO组和缬沙坦组,24只/组.对照组、摸型组以0.9%Nacl 2mL/d灌胃,治疗组在UUO组的基础上以缬沙坦30mg/kg溶解在0.9%Nacl 2mL/d灌胃.各组大鼠于术后第3,7,14天分别...
实验结果如下:毛囊形成期:(1)IHC-P实验结果显示:FGF21在E13天时表达于基底层细胞中,E14天表达于基底层和毛芽,E17、E18天主要表达在毛乳头;FGFR1在E13天主要表达于表皮和基底层中,E14天表达于表皮和毛芽,E15、E16天表达在表皮和毛钉中,E17、E18天表达于表皮及毛基质中;FGFR2在E13至E18天主要表达在表皮和...
NCAM knockdown in TAM_Ls revealed a significant decrease of migration and survival via a suppression of PI3K-Akt and fibroblast growth factor receptor 1 (FGFR1) signaling. Stimulation by TECM up-regulated the level of FGFR1 in Macrophage_Ls. Recombinant human fibroblast growth factor-2 (rhFGF-2...
Nuclear translocation of FGFR1 and FGF2 in pancreatic stellate cells is necessary for pancreatic cancer cell invasiondoi:10.1016/j.pan.2012.12.032taceyJ.ColemanAthina-MyrtoChioniMohammedGhallabRhysK.AndersonSDOSPancreatologyColeman SJ, Chioni AM, Ghallab M, Anderson RK, Lemoine NR, Kocher HM, Grose ...
The Fgf pathway is required around 30hpf for head cartilage formation.Receptors Fgfr1a and Fgfr2 are expressed in pharyngeal endoderm beyond 26hpf.Fgf signaling initiates a Runx3, Egr1, Sox9b regulatory cascade in pharyngeal endoderm.Fgfr1a and Fgfr2 are required for repression of the BMP inhibi...
Using comprehensive in vitro and in vivo methods and models, we reveal here for the first time an unexpected and surprising function of VEGF-B as an endogenous inhibitor of angiogenesis by inhibiting the FGF2/FGFR1 pathway when the latter is abundantly expressed. Mechanistically, we unveil that ...
基金 supported by the National Natural Science Foundation of China (Grant No. 91129706) 关键词 POLYSACCHARIDE CORDYCEPS Cordyceps militaris FGF BaF3 信号转导通路 硫酸多糖 冬虫夏草 野生 成纤维细胞生长因子 激活 生物合成 纯化 分类号 R284.2 [医药卫生—中药学] 相关...