例如,FGF-2 参与 JAK-STAT 信号通路来调控软骨代谢,也激活 ERK 信号促进软骨再生。FGF-2 结合 FGFR1/3 分别促进关节软骨的退化和修复。FGF-2 还是 GBM 中已知的致癌因子,有助于胶质瘤生长、血管化。重组小鼠 FGF-2 蛋白 (145a.a),是由 E.coli 大肠杆菌产生的重组蛋白,全长 145 个氨基酸,不带标签。
Using surface plasmon resonance and BAF3 cell arrays, we determined that HS fragments (released as a consequence of ESL degradation) may stimulate FGF2-FGFR1 signaling, inducing Ext1 expression in a human pulmonary microvascular endothelial cell line. Our findings suggest that the products of ESL ...
Pharmacological inhibition and siRNA knockdown of FGFR1 induced apoptosis in lung SCC cells. Our in vivo study indicated that honokiol could suppress the growth of xenograft tumors, and this effect was associated with the inhibition of the FGF2-FGFR1 signaling pathway. In conclusion, honokiol induced...
FGFR1基因所编码的蛋白质是属于成纤维细胞生长因子受体(FGFR)家族成员之一,目前已确定了四种由FGFRs, 即FGFR1、FGFR2、FGFR3和FGFR4。FGFR1是一种跨膜蛋白质,属于受体酪氨酸激酶,当FGF与FGFR1胞外段结合后,受体细胞内段酪氨酸激酶活性区首先发生自身磷酸化,然后使受体靶蛋白发生反式磷酸化,通过蛋白质级联反应将配体...
结果显示,高糖诱导会明显增加肾小管上皮细胞转分化的比例,并降低Klotho、FGFR1和FGF2的表达水平。而在高糖诱导下添加肾元颗粒后,发现其可以显著减少肾小管上皮细胞的转分化,并提高Klotho、FGFR1和FGF2的表达水平。此外,通过使用FGFR1抑制剂PD173074进一步验证了肾元颗粒通过Klotho/FGFR1/FGF2信号通路抑制高糖诱导的肾小...
FGF2/FGFR1 pathway when the latter is abundantly expressed. Mechanistically, we unveil that VEGF-B binds to FGFR1, induces FGFR1/VEGFR1 complex formation, and suppresses FGF2-induced Erk activation, and inhibits FGF2-driven angiogenesis and tumor growth. Our work uncovers a previously unrecognized ...
目的 观察不同时长电针干预对脑缺血再灌注大鼠成纤维细胞生长因子(FGF2)/成纤维细胞生长因子受体1(FGFR1)/磷酸化细胞外信号调节激酶(p-ERK)信号通路的调控作用,以及该通路对反应性星形胶质细胞极化的影响.方法 108只成年雄性SD大鼠随机分为假手术组,再灌注后1,3,5,7d模型组,再灌注后1,3,5,7d电针组,每组12只...
公开资料显示,这是一款靶向FGFR2b的抗体偶联药物(ADC),先声药业拟开发该产品治疗胃癌和肺癌等晚期恶性肿瘤。本次是该产品首次在中国获批IND。 成纤维细胞生长因子受体(FGFR)是成纤维细胞生长因子(FGF)的跨膜酪氨酸激酶受体,目前已知主要有FGFR1、FGFR2、FGFR3和FGFR4四种亚型。FGFR信号通过促进肿瘤细胞增殖、存活、迁...
The FGF2/FGFR1 paracrine loop is involved in the cross-talk between breast cancer cells and components of the tumor stroma as cancer-associated fibroblasts (CAFs). By quantitative PCR (qPCR), western blot, immunofluorescence analysis, ELISA and ChIP assays, we demonstrated that 17β-estradiol (E2...
摘要:目的观察成纤维细胞生长因子10(FGF10)、成纤维细胞生长因子受体(FGFR1、FGFR2)在昆明小鼠输卵管和子宫内的定位与分布。方法应用免疫组织化学法进行蛋白质定位观察。结果FGF10和FGFR1免疫阳性反应定位于昆明小鼠输卵管上皮细胞,FGFR2的免疫阳性反应见于肌层平滑肌。FGF10和FGFR1免疫阳性反应分布于昆明小鼠子宫内膜上皮、...