在氧化应激状态下,甲硫氨酸可通过硫转移途径(the sulphur-transfer pathway)转化为胱氨酸,合成谷胱甘肽,协助谷胱甘肽过氧化物酶抑制脂质活性氧生成,避免氧化性细胞损伤。因此硫转移途径可抑制铁死亡的发生;血红素加氧酶1(hemeoxygenase-1,HO-1)是细胞内铁的重要来源之一,Kwon等证实了其可以诱导脂质过氧化反应从而导致...
常规细胞凋亡或坏死常常伴随着细胞器肿大、染色质聚合、细胞膜完整性下降等特征,而细胞铁死亡在细胞形态上引起的改变甚微,往往只伴随细胞体积略微减小、线粒体膜密度增加等。 引发铁死亡通路(ferroptotic pathway)关键因素: ★ 贮藏在磷脂膜中的多不饱和长链脂肪酸(PUFAs) ★ 可氧化还原的铁离子 ★ 有缺陷的脂质过...
ironObjective This study aimed to explore the mechanism of hypertensive brain damage from ferroptosis pathway. Methods Ten 22-week-old SHR rats were labeled as hypertension group(HBP), while ten WKY rats of comparable age, weight were used as normal blood pressure group(NBP). After 2 weeks of...
PRMT4促进铁死亡加重阿霉素诱导的心肌病 2022-05-05报道,近日,中山大学第一附属医院的研究者们在Cell Death & Differentiation杂志上发表了题为“PRMT4 promotes ferroptosis to aggravate doxorubicin-induced cardiomyopathy via inhibition of theNrf2/GPX4 pathway”的文章,该研究显示,PRMT4抑制Nrf2/Gpx4信号通路以加速D...
2022-05-05报道,近日,中山大学第一附属医院的研究者们在Cell Death & Differentiation杂志上发表了题为“PRMT4 promotes ferroptosis to aggravate doxorubicin-induced cardiomyopathy via inhibition of the Nrf2/GPX4 pathway”的文章,该研究显示,PRMT4抑制Nrf2/Gpx4信号通路以加速DIC的铁死亡,提示靶向PRMT4可能是一种潜...
2022-05-05报道,近日,中山大学第一附属医院的研究者们在Cell Death & Differentiation杂志上发表了题为“PRMT4 promotes ferroptosis to aggravate doxorubicin-induced cardiomyopathy via inhibition of the Nrf2/GPX4 pathway”的文章,该研究显示,PRMT4抑制Nrf2/Gpx4信号通路以加速DIC的铁死亡,提示靶向PRMT4可能是一种潜...
Ferroptosisis an iron-dependent form of non-apoptotic cell death in which the complete mechanism is still unclear. It has emerged as a multifaceted pathway that reduces the size of the mitochondria, and leads to the rupture of the plasma membrane [121]. Molecularly, it results from an iron ...
Sanguinarine (SAG), an isoquinoline alkaloid, can promote the production of reactive oxygen species and inhibit the JAK/STAT pathway to promote apoptosis of lung cancer cells [216]. In addition to this, treatment of A549 and H3122 cells with SAG caused an increase in intracellular Fe2+concentrat...
E-cadherin-mediated intercellular contacts control ferroptosis sensitivity through the Merlin/Hippo/Yes-associated protein 1(YAP) pathway to regulate the expression of ACSL4 and transferrin receptor (TFR1) in response to cell-cell contacts.47Moreover, using unbiased genetic screens, ferroptosis suppressor...
In ferroptosis-related heart disease, a variety of effectors have been identified that play a cardioprotective role either by inhibiting oxidation mechanisms or by regulating antioxidant mechanisms, including the ferroptosis pathway. However, further research is needed before these agents can be used in ...