本文将一步一步回答ferroptosis ho1表达以及其在Ferroptosis中的功能。 第一部分:铁死亡(Ferroptosis)的概述 1.1 Ferroptosis的定义和特征 在细胞无法处理过量铁离子或失去铁离子平衡的情况下,Ferroptosis会被触发。不同于凋亡、坏死和自噬等已知的细胞死亡方式,Ferroptosis的特征包括细胞内多量的脂质过氧化产物和铁离子的...
一种细胞死亡方式叫做铁氧化物死亡(ferroptosis),它是一种非凋亡性细胞死亡方式,最近被发现与HO-1的表达和铁离子浓度有关。研究表明,HO-1在铁离子蓄积和铁氧化物死亡中发挥着重要的作用。HO-1可通过降低细胞内的游离铁离子浓度、增加金属蛋白的表达和促进铁离子的转运来减轻细胞的铁氧化物侵蚀。 HO-1在铁氧化物...
The expressions of ferroptosis-related factors (GPX4, SLC7A11 and PTGS2) and important antioxidant factors (NRF2, HO-1, GCLC and NQO1) were tested by real-time PCR, Western blot and immunofluorescence. Results demonstrated cisplatin-induced significant ROS and inflammatory factor relea...
此外,t-BHQ处理激活Nrf2或hemin处理激活HO-1部分逆转了RSL3和西妥昔单抗处理对HCT116和DLD-1细胞的生长抑制(图4G, H)。这些结果表明p38 MAPK参与调控Nrf2和HO-1的表达,西妥昔单抗可以通过p38 MAPK的激活抑制Nrf2/HO-1通路。 5. 在异种移植裸鼠模型中,西妥昔单抗通过抑制KRAS突变CRC细胞中的Nrf2/HO-1轴来...
在癌症研究领域中,Ferroptosis suppressor protein 1(FSP1)和Glutathione peroxidase 4(GPX4)已成为重要研究靶点。FSP1和GPX4作为细胞铁死亡通路的负调节因子,阻碍细胞铁死亡。其FSP1和GPX4抑制剂则能有效激活癌细胞的铁死亡,该类抑制剂的药物筛选也已成为研究新型抗癌治疗方法的热点项目。
We found that HG induced the initiation and development of ferroptosis in the kidney tissues of DN mice, and QCT attenuated diabetic kidney injury by inhibiting ferroptosis, which it accomplished by activating the NFE2-related factor 2 (Nrf2)/Heme oxygenase-1 (HO-1) signaling pathway. This ...
3.2. Ferrostatin-1 ameliorated DSS-induced UC via Nrf2/HO-1 signaling The transcription factor nuclear factor-erythroid 2 related factor 2 (Nrf2) is a master regulator of thecytoprotectiveprogram againstoxidative stress. According to WB analysis and RT-qPCR analysis, the expression of Nrf2 and HO...
Keywords: ferroptosis, tagitinin C, ROS, ER stress, Nrf2-HO-1 pathway IntroductionColorectal cancer is the fourth most common cancer cause of death globally, with about 2, 000, 000 new cases and 600, 000 deaths per year. The recorded incidence of colorectal cancer has been on the increase...
HO-1/BMMSC-derived exosomes enriched with miR-29a-3p, which downregulates IREB2, ameliorated liver tissue and hepatocyte injury and inhibited ferroptosis in vitro and in vivo [108]. In the same year, the team used the rat liver transplantation model with severe steatotic donor liver as the ...
(NRF2), HO-1, NOX4, and ACSL4 to promote ferroptosis [196,197,198,199,200,201]. Thus, the combination of TGF-β and ferroptosis could have a prospective therapeutic outlook and provide potential targets for cancer immunotherapy. XCT is associated with unfavorable prognosis for various types ...