Ischemic stroke is an acute cerebrovascular disease with a high morbidity, mortality, and disability rate. Persistent ischemia of brain tissue can cause irreversible damage to neurons, leading to neurological dysfunction and seriously affecting patients' quality of life . However, current clinical ...
Stroke Stroke is a disease caused by cell death caused by abnormal blood flow to the brain, and can be categorized into two types: ischemic stroke and hemorrhagic stroke. During hemorrhagic and ischemic strokes, the metabolic equilibrium of iron may become disrupted. On one hand, the upregulatio...
reference to ferroptosis as a regulatory cell death modalities, with varying degrees of crosstalk between autophagy, apoptosis, and necroptosis as RCD.The multiple RCD modes in ischemic core and penumbra play a beneficial, harmful or dual regulatory role in the progression of post-stroke brain ...
Ischemic stroke is a common neurological disease. Currently, there are no Food and Drug Administration-approved drugs that can maximize the improvement in ischemic stroke-induced nerve damage. Hence, treating ischemic stroke remains a clinical challenge. Ferroptosis has been increasingly studied in recent...
“Anti-ferroptosis exosomes engineered for targeting M2 microglia to improve neurological function in ischemic stroke.” Journal of nanobiotechnology vol. 22,1 291. 27 May. 2024 [3] Ko, Min Jun et al. “Magnetic nanoparticles for ferroptosis cancer therapy with diagnostic imaging.” Bioactive ...
Ischemic stroke represents a significant danger to human beings, especially the elderly. Interventions are only available to remove the clot, and the mechanism of neuronal death during ischemic stroke is still in debate. Ferroptosis is increasingly appre
in a mouse model of ischemic stroke, the level of GSH in neurons is significantly decreased, the degree of lipid peroxidation is enhanced, and the activity of GPX is decreased71. In addition, the use of ferroptosis inhibitors significantly improves the prognosis of patients with ischemic stroke72...
Electroacupuncture has been shown to play a neuroprotective role following ischemic stroke, but the underlying mechanism remains poorly understood. Ferroptosis has been shown to play a key role in the injury process. In the present study, we wa
[186]. Furthermore, FMT treatment can rescue ischemic stroke mice by improving gut microbiota and reducing ferroptosis. FMT reduces MDA and iron in the brain of ischemic stroke mice, elevates GSH levels, increases GPX4 and SLC7 A11 protein levels, and decreases TFR2 protein expression in the ...
Ischemic stroke rates have fallen worldwide over the past decade, but they have increased dramatically in East Asia, especially China [3,4,5]. Thus, plaque vulnerability has become an increasingly central issue in the treatment and prevention of carotid artery stenosis and stroke [1,6]. ...