Using Kyoto Encyclopedia of Genes and Gnomes (KEGG) pathway enrichment analysis, Yang et al. found that dexamethasone treatment induced activation of the ferroptosis pathway. EC-Exos could resist glucocorticoid-induced inhibition of osteoblasts by inhibiting ferrophagy-dependent ferroptosis in vitro and ...
KEGG通路富集 面议 基于机器学习算法的多组学疾病诊断/肿瘤预后预测模型 面议 肿瘤SNPs统计分析 面议 血管生成实验 面议 扫描电镜检测 面议 透射电镜检测 面议 CRISPR-Cas9敲除细胞系 面议 产品介绍 一、铁死亡简介铁死亡(Ferroptosis)最早是2012年由Brent R. Stockwell提出的[1],研究发现Erastin可以特异性诱导Ra...
50Under normal homeostasis, iron in systemic iron pools binds mainly to transferrin (TF) and is consumed in erythropoiesis. Senescent erythrocytes are devoured by macrophages, and the iron contained in the erythrocytes is then released into the systemic iron pool via FPN in...
These genes were further analyzed using GO, KEGG, and GSEA methods, and screened with PPI, LASSO, and SVM-RFE to identify ferroptosis-related diagnostic biomarkers for DN. A diagnostic model was established using the Glm function and verified with ROC curve. The relationship between these ...
Abbreviations: AI, artificial intelligence; ceRNA, competing endogenous RNA; CNN, convolutional neural network; DE-genes, differentially expressed genes; FDR, false discovery rate; GCN, graph convolutional network; GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; LASSO, least absolute...
(scRNA-seq) results revealed that multiple genes were differentially expressed in patients with intervertebral disc degeneration compared with those healthy individuals, and GO and KEGG analyses revealed that ferroptosis pathways were enriched with these differentially expressed genes; moreover, compared with...
Which KEGG pathways were indicated to be potentially impacted by Chrysotoxine (CTX)? Which key targets were found to interact with Chrysotoxine in the context of cervical cancer? What were the observed effects of increasing concentrations of Chrysotoxine (CTX) on HeLa cell proliferation? How might...
The GO and KEGG results revealed that these genes were mainly associated with various stress-related conditions and were enriched in multiple pathways, including “Protein processing in endoplasmic reticulum,”“MAPK signaling pathway,” and “Estrogen signaling pathway” (Fig. 4A-B). It has been ...
KEGG: Kyoto Encyclopedia of Genes and Genomes PCA: Principal component analysis NAFL: Non-alcoholic fatty liver NASH: Non-alcoholic steatohepatitis GPX4: Glutathione peroxidase 4 ROS: Reactive oxygen species ALD: Alcohol-associated liver disease HCC: Hepatocellular carcinoma HCV: Hepatitis C...
2B). Gene Set Enrichment Analysis (GSEA_KEGG_FERROPTOSIS) further revealed enrichment of ferroptosis-related genes in HCC samples with low METTL16 expression (Fig. S2C). Subsequent analysis employing the Cancer Therapeutics Response Portal (CTRP) database suggested a positive correlation between METTL...