Long-chain fatty acids (LCFAs) play important roles in cellular energy metabolism, acting as both an important energy source and signalling molecules1. LCFA-CoA esters promote their own oxidation by acting as allosteric inhibitors of acetyl-CoA carboxyla
Fatty acyl-CoA还原酶影响棉粉蚧的蜡质生物合成 粉蚧对多种植物具有高度攻击性。覆盖在珠被最外层的蜡质层是这些害虫的重要保护防御。然而,粉蚧中蜡质生物合成的分子机制仍然很大程度上未知。在这里,我们分析了棉粉蚧蜡质生物合成的多组学数据,发现在雌性粉蚧脂肪体中高表达的Fatty acyl-CoA还原酶 (PsFAR) 基因有助于...
Fatty acyl-CoAsynthetase (ACS) catalyzes the adenosine triphosphate dependent formation of athioesterbond between a fatty acid andcoenzyme A. This fundamental reaction allows the fatty acid to be degraded for energy production, incorporated into complexlipids, or participate in other metabolic pathways....
33. To study the metabolic phenotype of these aggressive B-cell lymphomas, we generated CD37-deficient human DLBCL cell lines (BJAB, OciLy1) using CRISPR/Cas9 technology and used a CD37-deficient mouse model20. Oxygen
Functional characterization of thioesterase superfamily member 1/Acyl-CoA thioesterase 11: implications for metabolic regulation. Thioesterase superfamily member 1 (Them1; synonyms acyl-CoA thioesterase 11 and StarD14) is highly expressed in brown adipose tissue and limits energy expe... S Han,DE Cohen...
Acyl CoAs Analysis Carnitine Analysis TCA Cycle Analysis NAD Metabolites Analysis Fatty Acid Synthesis Fatty acid synthesis, or lipogenesis, is the process by which excess carbohydrates are converted into fatty acids. It predominantly occurs in the cytoplasm and involves several enzymatic steps. ...
Polyketide synthases (PKS) utilize acyl-coenzyme A (CoA) precursors and synthesize polyketides by repetitive decarboxylative condensations. Here we show that acyl-CoA ligases, which belong to a large family of acyl-activating enzymes, possess potential to produce varied starter CoA precursors that ...
cerevisiae, activation of exogenous long-chain fatty acids to coenzyme A derivatives, prior to metabolic utilization, proceeds through the fatty acyl-CoA synthetases Faa1p and Faa4p. It has been shown that free fatty acids are secreted from a FAA1,4 double mutant (2). This modification will ...
Metabolic diseasesLong-chain acyl-coenzyme A (CoA) synthase 4 (ACSL4) is an enzyme that esterifies CoA into specific polyunsaturated fatty acids, such as arachidonic acid and adrenic acid. Based on accumulated evidence, the ACSL4-catalyzed biosynthesis of arachidonoyl-CoA contributes to the ...
Once the PUFAs are within the cell, FATPs act via fatty acyl-CoA synthetase (ACS) activity to promote the activation of intracellular fatty acids and prevent the efflux of PUFAs [53,54]. The long-chain fatty acyl-CoA derivatives act not only as substrates but also intermediates in ...