Once activated, fatty acyl-CoA molecules can undergo different metabolic fates depending on the cell's energy demands and metabolic state. They can enter mitochondrial beta-oxidation, as mentioned earlier, where they are broken down to produce acetyl-CoA and generate energy. Alternatively, fatty acyl...
Acyl-CoAs play a crucial role as intermediates in various metabolic processes, including fatty acid oxidation, fatty acid synthesis, cholesterol metabolism, and ketogenesis. Fatty Acid Oxidation: Acyl-CoAs are central to the process of fatty acid oxidation, which occurs primarily in the mitochondria....
as fatty acids are key substrates for this metabolic pathway. Understanding how different fatty acids impact this process helps elucidate the broader metabolic context of peroxisomal dysfunction in muscle cells. We observed that exposure to certain fatty acids, such as palmitic acid (PA), dicarboxylic...
Since enzymes are selective for their substrates and speed up only a few reactions from among many possibilities, the set of enzymes made in a cell determines which metabolic pathways occur in that cell.doi:10.1007/978-3-642-58051-2_81Professor Dr. Dietmar Schomburg...
Metabolic Fates of Acetyl CoA 18 related questions found How is acyl-CoA Synthesised? Acetyl-CoA is producedby the breakdown of both carbohydrates (by glycolysis) and lipids (by β-oxidation). It then enters the citric acid cycle in the mitochondrion by combining with oxaloacetate to form citrat...
RNA-sequencing was then performed to explore the potential mechanisms and transcriptional changes in the process. The metabolic pathway, biosynthesis of polyunsaturated fatty acid was significantly altered in DOX-treated murine heart, and Acot1 was one of the leading-edge core genes. We then ...
- 《Journal of Inherited Metabolic Disease》 被引量: 99发表: 2004年 First prenatal diagnosis of acyl-CoA oxidase deficiency The presence of a nonspecific NADPH-linked aldehyde reductase (alcohol-NADP oxidoreductase, EC 1.1.1.2) from heart was observed in the soluble portion of t... RJA Wanders...
Structure and Metabolic Role of Acyl-CoAs Acyl-CoAs consist of an acyl residue, bound as thioester to the thiol group of the pantetheine residue of Coenzyme A (CoA), (Fig.1). Fig. 1 Authors and Affiliations Joanneum Research, HEALTH – Institute for Biomedicine and Health Sciences, Graz...
Acyl-CoAs are essential for many physiological processes, like lipid synthesis, fatty acid oxidation, ketone body generation, xenobiotic metabolism, and signaling transduction. Generally speaking, acyl-CoAs like free CoA, acetyl-CoA, and malonyl-CoA assist in regulation of metabolic flux. For ...
The direct oxidation of OPDA would imply that OPR3 activity may be switched on and off depending upon the metabolic needs of the cell. In the absence of OPR3 activity, OPDA may be oxidised to 4, 5-didehydro-JA [51,63]. View article Peroxisomes as cellular adaptors to metabolic and ...