Once activated, fatty acyl-CoA molecules can undergo different metabolic fates depending on the cell's energy demands and metabolic state. They can enter mitochondrial beta-oxidation, as mentioned earlier, where they are broken down to produce acetyl-CoA and generate energy. Alternatively, fatty acyl...
Acyl-CoAsare intermediates of numerous metabolic processes in eukaryotic cells, including beta-oxidation within mitochondria and peroxisomes, and the biosynthesis/remodeling of lipids (e.g. mono-, di-, and triglycerides, phospholipids and sphingolipids). Investigations of lipid metabolism have been advan...
Acyl-CoAs play a crucial role as intermediates in various metabolic processes, including fatty acid oxidation, fatty acid synthesis, cholesterol metabolism, and ketogenesis. Fatty Acid Oxidation: Acyl-CoAs are central to the process of fatty acid oxidation, which occurs primarily in the mitochondria....
Fig. 1. Metabolic fates of activated FAs. Most pathways of cellular FA metabolism require prior activation of the FA by thioesterification to CoA. The ACS isoform that participates in a specific pathway is frequently dependent upon the tissue, cell type, subcellular location, and FA chain length...
Metabolic Fates of Acetyl CoA18 related questions found How is acyl-CoA Synthesised? Acetyl-CoA is produced by the breakdown of both carbohydrates (by glycolysis) and lipids (by β-oxidation). It then enters the citric acid cycle in the mitochondrion by combining with oxaloacetate to form ...
Reconstitution of EPA and DHA biosynthesis in Arabidopsis: Iterative metabolic engineering for the synthesis of n-3 LC-PUFAs in transgenic plants. Metab. Eng. 17, 30–41 (2013). Article CAS PubMed PubMed Central Google Scholar Harwood, J. L. Algae: critical source of very long-chain ...
Structure and Metabolic Role of Acyl-CoAs Acyl-CoAs consist of an acyl residue, bound as thioester to the thiol group of the pantetheine residue of Coenzyme A (CoA), (Fig.1). Fig. 1 Authors and Affiliations Joanneum Research, HEALTH – Institute for Biomedicine and Health Sciences, Graz...
RNA-sequencing was then performed to explore the potential mechanisms and transcriptional changes in the process. The metabolic pathway, biosynthesis of polyunsaturated fatty acid was significantly altered in DOX-treated murine heart, and Acot1 was one of the leading-edge core genes. We then ...
Collectively, these observations support-the biochemical evidence tabulated from previous reports that the ACS gene family is responsible for providing acyl-CoA substrates for a number of distinct metabolic pathways that are carried out under conditions that vary considerably with respect to tissue type,...
MicroRNA-23b regulates the acyl-CoA metabolic process via Acyl-CoA thioesterase 4 (Acot4), which interacts with Acetyl CoA Carboxylase (ACC), according to the RNA-seq analysis.doi:10.1016/j.yexcr.2021.112787Hongzhi Li aXiang Li aShanshan Yu a c...