metabolic engineering MGAT acyl-CoA:monoacylglycerol acyltransferase MGD monogalactosyldiacylglycerol synthase MGDG monogalactosyldiacylglycerol MS mass spectrometry NBD N-[(7-nitro-2-1,3-benzoxadiazol-4-yl)-methyl]amino NAFLD non-alcoholic fatty liver disease ...
We use it to create a pool of acyl-CoA’s that can be redirected to oleochemical products. Through bioprospecting, mutagenesis, and metabolic engineering, we develop three strains of Escherichia coli capable of producing over 1 g/L of medium-chain free fatty acids, fatty alcohols, and ...
These findings suggest that under biological conditions, Them1 functions as a lipid-regulated fatty acyl-CoA thioesterase that could be targeted for the management of metabolic disorders. 展开 关键词: long-chain fatty acyl-CoA free fatty acid brown adipose tissue liver recombinant protein START ...
The acyl-CoA-binding protein (ACBP) is a 10-kDa intracellular lipid-binding protein that transports acylCoA esters. The protein is expressed in most cell types at low levels; however, expression is particularly high in cells with a high turnover of fatty acids. Here we confirm a previous ...
1999. Unusually high standard redox potential of acrylyl-CoA/ propionyl-CoA couple among enoyl-CoA/acyl-CoA couples: a reason for the distinct metabolic ... Sato,Nishina,Setoyama,... - 《Journal of Biochemistry》 被引量: 86发表: 1999年 Unusually High Standard Redox Potential of Acrylyl-CoA...
The incidence of severe metabolic crises in medium chain acyl-CoA dehydrogenase deficiency (MCADD) patients homozygous for the common c.985A > G mutation, who had been identified by neonatal screening, was assessed prospectively and compared to retrospective cohort data in unscreened patients with id...
Since these desaturases appear to be found only in moth sex pheromone glands, we have been interested in their possible evolution from an ancestral gene encoding a metabolic Δ9-acyl-CoA desaturase, which occurs commonly in animal and fungal tissues. Evolution of novel desaturation mechanisms could...