Mitochondrial acyl-CoA metabolism is essential for energy production within the cell. It involves the generation of acetyl-CoA from pyruvate through the action of pyruvate dehydrogenase in the mitochondria. Acetyl-CoA serves as a central hub for multiple metabolic pathways in the mitochondria, including...
Acyl-CoA: Acyl-CoAs serve as key intermediates in various metabolic pathways. They are involved in fatty acid oxidation, fatty acid synthesis, amino acid metabolism, cholesterol metabolism, and the synthesis of specialized lipids. Acyl-CoAs act as carriers of acyl groups, enabling the transport a...
"Metabolism of acyl-CoA in the developing rat brain." Dev Neurosci 4(5): 337-344.Smith, R. E., and Sun, G. Y., 1981, Dev. Neurosci. 4 :337–344.Smith R . E . and Sun G . Y. (1981) Metabolism of acyl-CoA in the developing rat brain . Dev . Neurosci. 4, 337-344 ....
Long-chain fatty acids (LCFAs) play important roles in cellular energy metabolism, acting as both an important energy source and signalling molecules1. LCFA-CoA esters promote their own oxidation by acting as allosteric inhibitors of acetyl-CoA carboxylase, which reduces the production of malonyl-Co...
metabolism genes in mouse models of muscle atrophy, highlighting the importance of peroxisomal β-oxidation in acyl-CoA metabolism (Fig. 6C). Enrichment signaling pathways included long-chain fatty acyl-CoA ligase activity, ABCD-type peroxisomal import, and glycerolipid metabolism. Direct exposure to ...
The low density lipoprotein (LDL) receptor system coordinates the metabolism of cholesterol, an essential component of the plasma membrane of all mammalian... BJL Goldstein - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量: 2989发表: 1979年 The cholester...
Unveiling the Crucial Role of Peroxisomal Acyl-CoA Metabolism in Muscle Atrophy: Insights from Genetic Models and Therapeutic Interventions 来自 dx.doi.org 喜欢 0 阅读量: 3 作者:S Jiang,SK Han,HR Ji,YS Lee,DI Kim,EJ Jin 摘要: Peroxisome dysfunction linked to sarcopenia and muscle degeneration...
Long chain acylCoA esters (LCAs) act both as substrates and intermediates in intermediary metabolism and as regulators in various intracellular functions. AcylCoA binding protein (ACBP) binds LCAs with high affinity and is believed to play an important role in intracellular acylCoA transport and poo...
Rather, our data support the hypothesis that Acsl6 functions primarily in DHA metabolism, and that its overexpression increases DILA and AA internalization primarily during the first 24 h of neuronal differentiation to stimulate PL synthesis and enhance neurite outgrowth. 展开 ...
Fatty acyl-CoA dehydrogenase deficiencies are defined as disorders of the metabolism of straight chain acyl-CoA esters at the level of short chain acyl-CoA, general (medium chain) acyl-CoA and long chain acyl-CoA dehydrogenases. Patients with proven or indicated defects in either general (medium...