Schulte MB, Moley KH (2014) The fatty acid beta-oxidation pathway is important for decidualization of endometrial stromal cells in both humans and mice. ... MB Schulte,MY Chi,JH Tsai,... - 《Biology of Reproduction Offical Journal of the Society for the Study of Reproduction》 被引量: 17...
Methods of treating mitochondrial fatty acid β-oxidation and/or transport disorders arising from mutant proteins in the mitochondrial fatty acid β-oxidation and transport metabolic pathways in patients are provided. The methods modulate the mitochondrial fatty acid β-oxidation pathway at the last step...
Figure 3. Downregulation of ACSL4 inhibits FA β-oxidation and lipid droplet synthesis. A. Pattern diagram of fatty acid activation through ACSL4 into anabolism and catabolism. The ESCs were treated with 1 μM MPA and 0.5 mM db-cAMP for 3, 5, and 7 days, and intracellular lipid droplet ...
Metabolic engineering of Escherichia coli for 1-butanol biosynthesis through the inverted aerobic fatty acid β-oxidation pathway Metabolic engineering of Escherichia coli for 1-butanol biosynthesis through the inverted aerobic fatty acid beta-oxidation pathway. Biotechnol. Lett... AY Gulevich,AY Skorokhod...
Fatty acid β-oxidation and its regulation Fats are stored in our body as triacylglycerols (TAGs) which are hydrolyzed into free fatty acids and glycerol by lipases as the first step of lipid catabolism. The fatty acid β-oxidation pathway consists of multistep reactions which oxidizes fatty acid...
Acute infection is known to induce rapid expansion of hematopoietic stem cells (HSCs), but the mechanisms supporting this expansion remain incomplete. Using mouse models, we show that inducible CD36 is required for free fatty acid uptake by HSCs during a
et al. Development of oxaalkyne and alkyne fatty acids as novel tracers to study fatty acid beta-oxidation pathways and intermediates. J. Lipid Res. https://doi.org/10.1016/j.jlr.2022.100188 (2022). Herzog, R. et al. A novel informatics concept for high-throughput shotgun lipidomics based...
Beta-Oxidation Mechanism The beta-oxidation of fatty acids involvesthree main processes. The first step of the pathway is fatty acid activation in the cytoplasm, followed by the transport of fatty acids into the mitochondria. Finally, beta-oxidation happens in the mitochondrial matrix. ...
Fatty Acid Synthesis Pathway Fatty acid synthesis encompasses a complex series of enzymatic reactions that involve the conversion of acetyl-CoA to malonyl-CoA, followed by the sequential addition of two-carbon units to elongate the growing fatty acid chain in the fatty acid synthase (FAS) complex....
During activation, T cells undergo metabolic reprogramming, which imprints distinct functional fates. We determined that on PD-1 ligation, activated T cells are unable to engage in glycolysis or amino acid metabolism but have an increased rate of fatty a