Interestingly, several proteins involved in the fatty acid 尾-oxidation pathway, including ACSL1, ACADS, and ACOX1, were up-regulated by Leu deprivation. In addition, Leu deprivation led to the reduction of cellular triglycerides in HepG2 cells. These results reveal that the fatty acid 尾-...
The fatty acid beta-oxidation pathway is important for decidualization of endometrial stromal cells in both humans and mice. The fatty acid beta- oxidation pathway is important for decidualization of endometrial stromal cells in both humans and mice. Biol Reprod. 2014;90:34... MB Schulte,MY Chi...
Peroxisomal branched chain fatty acid beta-oxidation pathway is upregulated in prostate cancer. Prostate 2005; 63: 316–323. Article CAS PubMed Google Scholar Samudio I, Harmancey R, Fiegl M, Kantarjian H, Konopleva M, Korchin B et al. Pharmacologic inhibition of fatty acid oxidation ...
Figure 3. Downregulation of ACSL4 inhibits FA β-oxidation and lipid droplet synthesis. A. Pattern diagram of fatty acid activation through ACSL4 into anabolism and catabolism. The ESCs were treated with 1 μM MPA and 0.5 mM db-cAMP for 3, 5, and 7 days, and intracellular lipid droplet ...
Metabolic engineering of Escherichia coli for 1-butanol biosynthesis through the inverted aerobic fatty acid β-oxidation pathway Metabolic engineering of Escherichia coli for 1-butanol biosynthesis through the inverted aerobic fatty acid beta-oxidation pathway. Biotechnol. Lett... AY Gulevich,AY Skorokhod...
Acute infection is known to induce rapid expansion of hematopoietic stem cells (HSCs), but the mechanisms supporting this expansion remain incomplete. Using mouse models, we show that inducible CD36 is required for free fatty acid uptake by HSCs during a
Beta-Oxidation Mechanism The beta-oxidation of fatty acids involvesthree main processes. The first step of the pathway is fatty acid activation in the cytoplasm, followed by the transport of fatty acids into the mitochondria. Finally, beta-oxidation happens in the mitochondrial matrix. ...
This chapter focuses on the methods to measure unique metabolites, specific enzymes, and genes in fatty acid oxidation and monitor metabolic flux through the entire pathway. It also describes the methods for the diagnosis of diseases of fatty acid oxidation. Frequently, patients are identified in wh...
Fatty Acid Synthesis Pathway Fatty acid synthesis encompasses a complex series of enzymatic reactions that involve the conversion of acetyl-CoA to malonyl-CoA, followed by the sequential addition of two-carbon units to elongate the growing fatty acid chain in the fatty acid synthase (FAS) complex....
miR-30e enhances fatty acid β-acid oxidation, promoting oxidative stress and EC dysfunction in vitro Since miR-30d/e regulate fatty acid biosynthesis and metabolism pathway components, we investigated the impact of modulating miR-30 levels on EC responses to exposure to free fatty acids (FFAs)....