(1) Know about β-oxidation of fatty acids.(2) Master the method to determine β-oxidation as well as its principle. 2. Principle In livers, fatty acids can be transformed into acetyl coenzyme A via β-oxidation. Two molecules of acetyl coenzyme A will condense and generate acetoacetic acid...
inter-relationship of the RL and PHA biosynthetic pathways in a culture medium with a non-fatty acid carbon source, focusing on the role of FASII and beta-oxidation in supplying the substrates for the first step in RL and PHA synthesis, carried out by the RhlA and PhaG enzymes, ...
Fatty acid synthesis involves the de novo assembly of acetate into saturated fatty acids as well as the desaturation and elongation of the dietary essential fatty acids – linoleic acid (C18:2n-6) and α-linolenic acid (C18:3n-3) – to highly unsaturated 20- and 22-carbon fatty acids essen...
Fatty acid synthesisoccurs in the cytosol, but is essentially the reverse ofβ-oxidation of fatty acids (although it employs a separate set of enzymes), whereby fatty acids are synthesized from the successive additions of 2C acetyl-CoA, followed by reduction. ...
Over-expression of miR-30e in cultured ECs increased fatty acid β-oxidation and the production of reactive oxygen species and lipid peroxidation, while inhibiting the miR-30 family decreased fatty acid β-oxidation. Additionally, miR-30e over-expression synergized with fatty acid exposure to down-...
Yang SY, He XY (1999) Molecular mechanisms of fatty acid (3-oxidation enzyme catalysis. In: Current Views of Fatty Acid Oxidation and Ketogenesis: From... Yang,SY,XY - 《Advan Experiment Med Biol》 被引量: 0发表: 1999年 Acyl-CoA dehydrogenases - a mechanistic overview fatty acid beta-ox...
Acute infection is known to induce rapid expansion of hematopoietic stem cells (HSCs), but the mechanisms supporting this expansion remain incomplete. Using mouse models, we show that inducible CD36 is required for free fatty acid uptake by HSCs during a
Adipocytes are the primary sites for fatty acid storage, but the synthesis rate of fatty acids is very low. The physiological significance of this phenomenon remains unclear. Here, we show that surplus fatty acid synthesis in adipocytes induces necroptos
结果表明了miR-140是TGFA的上游调控因子,miR-140能抑制(P < 0.01)牛乳腺上皮细胞(BMECs)和甘油三酯(TAGs)产生;相反,TGFA促进(P < 0.01)不饱和脂肪酸和TAG生成。拯救实验进一步表明了miR-140/TGFA调控机制。综上所述,这些结果表明了miR-140/TGFA通路可以抑制(P < 0.01)奶牛乳腺上皮细胞中的乳脂代谢的进行,...
The synthesis of a new methyl-branched fatty acid, (E)-19-iodo-3(RS)-methyl-18-nonadecenoic acid (19), is described. Methyl branching has been introduced at the 3-position to inhibit beta-oxidation and radioiodide has been attached as a trans-vinyl iodide. Preparation of 19 involved a ...