MELK knockdown could also decrease the phosphorylation level of AKT through FAK/Src pathway. Our results indicated downregulation of MELK retarded the progression of CRC by inhibition of the phosphorylation level of AKT through inactivating FAK/Src pathways. Therefore, MELK has the potential to be ...
These results were verified in HL-1 cells treated with high hydrostatic pressure, and demonstrated that electrical remodeling regulated by the FAK-Src pathway could be modulated by valsartan. The present study indicated that high hydrostatic pressure stimulation increases AF susceptibility by activating ...
Src、FAK、PI3K、ERK、AKT Receptoractivation press EGF、PDGFR···RTKs SrcFAK sos Ras-GTP sosGrb2 Src-DependentFAK-AktPATHWAY PI3K-AKTPATHWAY ERK1/2 PATHWAY PI3K c-Raf PIP2PIP3 RALGDS MEK1/2 AKT/PKB BAD GEFIKK ···ERK1/2ELK-1···CASPASE9 AFX RAC1 NFκBExpressionofanti-apoptotic...
产品活性:FAP 蛋白是一种跨膜丝氨酸蛋白酶,通过激活 PI3K/AKT、SHH/GLI 和 FAK-Src-STAT3 等信号通路,在细胞增殖、纤维化、伤口愈合、炎症和肿瘤生长中发挥多种作用。 FAP 蛋白, Human (HEK293, His) 是由 HEK293 表达的重组蛋白,N 端带有 His 标签,全长 735 个氨基酸 (L26-D760)。 生物活性:通过其将...
Key wo rd s: Focal adhesion kinase Development Tumor Signal transduction 粘附斑激酶 ( focal adhesion kinase, FAK)是一种 胞质非受体蛋白酪氨酸激酶 ,是粘附斑复合物家族 ( focal adhesion comp lex fam ily) 的一员 .上世纪 90 年代早期 , Kanner等 在[ 1 ] v2src 转染鸡胚成纤维细 胞后 ,发现有...
Collagen Gel Contraction by ARPE-19 cells is mediated by a FAK-Src dependent pathway. Exp Eye Res. 2007;85(6):790 -798.Morales S, Mareninov S, Prasad P, Wadehra M, Braun J, Gordon LK. Collagen gel contraction by ARPE-19 is mediated by a FAK-Src dependent pathway. Exp Eye Res. ...
Created with Sketch. 图:1/4 Phospho-FAK (Tyr397) Antibody (PA5-17084) in WB Western blot analysis of Phospho-FAK pTyr397 in extracts from NIH/3T3 cells, untransfected or transfected with activated Src, using Phospho-FAK pTyr397 polyclonal antibody (Product # PA5-17084) (upper) or a PTK...
PI3K-AKT PATHWAY,c-Raf,MEK1/2,ERK1/2,ELK-1 ,RALGDS,AKT/PKB,PIP2,PIP3,GEF,RAC1,NFB,IKK,Expression of anti-apoptotic genes,BAD,CASPASE9,AFX,BCL-XL,EGF、PDGFR,CASPASE CASCADE PATHWAY,Fas Ligand Expression,Apoptosis,Anti-Apoptosis,cell differentiation,Src,Src-Dependent FAK-Akt PATHWAY,3 ...
These findings reveal a novel role for Src/FAK pathway kinases in drug resistance and identify dasatinib as a potential therapeutic for treatment of erlotinib resistance associated with EMT. 展开 关键词: EMT, Src, drug resistance, dasatinib, cancer ...
关键词: 粘附斑激酶发育 肿瘤 信号通路 inFocalAdhesion Kinase Progress SignalingPathway LiShuyuWangZhigang Mammal (Collegeofz咖Science,InnerMongoliaUniversity,TheKeyLaboratoryof ReproductiveBiology and Biotechnology,MinistryofEducation,Huhhot010021) adhesion a Abstract:Focal tothe kinase(FAK)iscytoplasmicnonreeep...