& Liao, K. Tyrosine phosphorylation of cortactin by the FAK-Src complex at focal adhesions regulates cell motility. BMC Cell Biol. 12, 49 (2011).Wenqi Wang,Yang Liu,Kan Liao.Tyrosine phosphorylation of cortactin by the FAK-Src complex at focal adhesions regulates cell motility. BMC Cell ...
In ErbB2-transformed cells, p130Cas is a crucial component of a functional molecular complex consisting of ErbB2, c-Src, and Fak. In human mammary ... S Cabodi,A Tinnirello,B Bisaro,... - 《Faseb Journal Official Publication of the Federation of American Societies for Experimental Biology...
YH-306 suppresses the activation of FAK, c-Src, paxillin, and PI3K, Rac1, and the expression of MMP2 and MMP9. YH-306 potently suppresses uninhibited proliferation and induces cell apoptosis. YH-306 inhibits Arp2/3 complex-mediated actin polymerization[1]. ...
Given that Rac1 could be activated at the downstream to promote the lamellipodia formation along the flow direction20, the HSS-induced polarity of Src-FAK complex may coordinate with Rac1 activation in regulating the cell shape and alignment along the flow. Methods BAECs transfected with various ...
The dual kinase complex FAK-Src as a promising therapeutic target in cancer. Onco Targets Ther. 3, 83–97 (2010). CAS PubMed PubMed Central Google Scholar Orgaz, J. L. et al. Diverse matrix metalloproteinase functions regulate cancer amoeboid migration. Nat. Commun. 5, 4255 (2014). ...
Therefore, further research should examine whether HOXA13 can activate the Erk and PI3K-Akt signaling pathways through the FAK/Src complex to promote GC progression. Western blot analysis showed that HOXA13 overexpression increased the phosphorylation levels of FAK, Src, Erk1/2, and Akt, which ...
YH-306 suppresses the activation of FAK, c-Src, paxillin, and PI3K, Rac1, and the expression of MMP2 and MMP9. YH-306 potently suppresses uninhibited proliferation and induces cell apoptosis. YH-306 inhibits Arp2/3 complex-mediated actin polymerization[1]. ...
Integrin/caveolae mechanosignaling complex regulates p190RhoGAP phosphorylation, RhoA activity and MLC phosphorylation, eventually effecting actin stress fiber formation. Shear flow however does not alter the expression of downstream signaling molecules when silencing β1 integrin and Cav-1 in endothelial ...
The integrin complex αvβ3 participates in the adhesion of microvascular endothelial cells to fibronectin - ScienceDirect Fibronectin is a major adhesive glycoprotein of the vascular basement membrane. Since fibronectin is also found in the interstitium, it may be important no... Yao-Fen,Cheng,and...
complex is required for the dorsoventral repulsion of both neurons and gonads in C. elegans. The biological functions of netrin and its receptors in axon growth and growth cone guidance have been well studied; the intracellular signal transduction pathways downstream of the netrin ...