Microcatheter-directed administration of thrombolytics at the level of common and proper digital arteries resulted in the salvage of the ring finger to the level of the distal tuft and the entirety of the small finger.#Heterozygous factor V Leiden mutation is an extremely unusual etiology for ...
Factor V Leiden refers to the c.1691G>A variant in the FV gene, which encodes coagulation factor V. This variant results in resistance to factor V protein degradation by activated protein C and increases the risk of VTE 6 to 8 fold in heterozygous carriers and 80 fold in homozygous carrier...
Activated protein C resistance, caused by a point mutation factor V gene was described in last decade. This article highlights a case of a 9 year-old-boy who admitted to Baskent University Hospital with right- sided hemiplegia. He was diagnosed as heterozygous for the FVL mutation and with ...
It is well documented that factor V Leiden mutation (FVL) is a common hypercoagulable risk factor in the Caucasian population. Patients with homozygous FVL mutation have an increased risk for venous thromboembolism. However, there have been few cases of heterozygous FVL mutation associated with ...
3. De Stefano Ⅴ, Martinelli I, Leone G, et al. The risk of recurrent deep venous thrombosis among heterozygous carriers of both factorⅤ Leiden and the G20210A prothrombin mutation [J]. N Engl J Med, 1999, 341(11):801-806.
In a re- cent study of thrombophilic families, individuals homozygous for Factor V Leiden or doubly heterozygous for Factor V Leiden and the prothrombin 20210GϾA mutations did not have an increased risk for recurrence, even when the analysis was restricted to those with a first idiopathic VTE...
Another variant, called the R2 allele (H1299R), appears to confer a modest additional increased thrombotic risk when present in the compound heterozygous state with factor V Lei- den.20 It has no clinically significant effect by itself, but in the homozygous state, it appears to increase APC...
We report here the evolution of the thrombin generation profile while taking combined oral contraceptives and after their discontinuation in a woman with heterozygous factor V Leiden mutation. The proband exhibited a distinctly prothrombotic thrombin generation profile including markedly decreased thrombomodulin...
Presents a letter to the editor regarding a Budd-Chiari syndrome with underlying homozygous factor V Leiden and heterozygous methylenetetrahydrofolate reductase mutations.doi:10.1007/s00535-005-1664-2Kassem A. BaradaCecilio R. AzarZaher K. Otrock...
Stroke in a Neonate Heterozygous for Factor V Leiden Activated protein C resistance is the most common hereditary coagulation abnormality and is caused by the factor V Leiden mutation. A newborn who developed... PN Varelas,BJ Sleight,HM Rinder,... - 《Pediatric Neurology》 被引量: 51发表: ...