The rate of early and late fetal loss was assessed and was compared among factor V Leiden homozygous, factor V Leiden heterozygous, and noncarriers, and the impact of concomitant thrombophilic abnormalities was examined. Results show that risk of fetal loss is higher in women who were homozygous...
CONCLUSION: The factor V Leiden homozygous genotype increases the risk of late fetal loss. However, the overall likelihood of a positive outcome is high in our series of women who were homozygous. LEVEL OF EVIDENCE: III. 展开 关键词:
The association between adverse pregnancy outcomes and maternal factor V Leiden genotype: a meta-analysis. Thromb Haemost 2004;91:700 –711. 92. Kovalevsky G, Gracia CR, Berlin JA, Sammel MD, Barnhart KT. Evalu- ation of the association between hereditary thrombophilias and recurrent pregnancy ...
Patients (n = 1600) from 12 European countries, scheduled for elective orthopaedic hip or knee surgery, were screened for Factor V Leiden and prothrombin g... K W?Hlander,G Larson,TL Lindahl,... - 《Thrombosis & Haemostasis》 被引量: 249发表: 2002年 Allele-specific genotype detection of...
We determined the factor V Leiden genotype in 471 consecutive patients aged less than 70 years with a first objectively confirmed deep-vein thrombosis and in 474 healthy controls. We found 85 heterozygous and seven homozygous individuals among the cases with thrombosis and 14 heterozygous individuals ...
2.mutation- (genetics) any event that changes genetic structure; any alteration in the inherited nucleic acid sequence of the genotype of an organism chromosomal mutation,genetic mutation genetic science,genetics- the branch of biology that studies heredity and variation in organisms ...
Synonyms for Factor V Leiden mutation in Free Thesaurus. Antonyms for Factor V Leiden mutation. 34 synonyms for mutation: anomaly, variation, deviant, freak of nature, change, variation, evolution, transformation, modification, alteration, deviation...
After getting an 80% amplification success for amelogenin, a melting curve analysis using lightcycler was performed to determine the FVL genotype of each sample. Of the 60 samples, 1 gave a positive amplification result for FV gene and was found to be heterozygous. To date, the age of this ...
The study population consisted of 150 subjects whose factor V genotype was previously determined by PCR-RFLP method using the Mnl I restriction endonuclease. A 223-bp fragment containing the G1692-A (Arg 506-Gln) polymorphic site in exon 10 of the factor V gene was amplified, denatured, and...
None of the PVT children were heterozygous or homozygous for the factor V Leiden, and one control child was heterozygous. This study demonstrates that factor V Leiden is not common in children with PVT, and is not a prerequisite for this thrombotic event. 展开 ...