The rate of early and late fetal loss was assessed and was compared among factor V Leiden homozygous, factor V Leiden heterozygous, and noncarriers, and the impact of concomitant thrombophilic abnormalities was examined. Results show that risk of fetal loss is higher in women who were homozygous...
Twitter Google Share on Facebook (redirected fromFactor V Leiden mutation) Thesaurus Medical Legal Acronyms Encyclopedia mu·ta·tion (myo͞o-tā′shən) n. 1.The act or process of being altered or changed. 2.An alteration or change, as in nature, form, or quality. ...
Women in the preeclampsia cohort (n=283) were genotyped for both the Leiden variant (G1691A) of factor V and the thermolabile variant (C677T) of methylenetetrahydrofolate reductase. Genotype and allele frequencies were compared with those of 2 control groups, one consisting of women recruited ...
The association between adverse pregnancy outcomes and maternal factor V Leiden genotype: a meta-analysis. Thromb Haemost 2004;91:700 –711. 92. Kovalevsky G, Gracia CR, Berlin JA, Sammel MD, Barnhart KT. Evalu- ation of the association between hereditary thrombophilias and recurrent pregnancy ...
All patients, unaware of their genotype, received a structured questionnaire. RESULTS: Of the 297 (86%) women who returned the questionnaire, 220 had been pregnant at least once. Time to first pregnancy was unaffected by carrier status: 58% factor V Leiden carriers reported a pregnancy within ...
On the other hand, the increased risk of venous thrombosis in individuals with homozygous FII c.*97G > A mutation is not clear due to the relatively rarity of individuals with this genotype [16]. Also, since population-based screening of FVL and PT mutation in otherwise healthy individuals ...
217 The factor V Leiden mutation associated with APC resistance results in the continued activation of thrombin in the prothrombinase complex. Although a significant association has been established between the incidence of venous thrombosis and the factor V Leiden mutation, the influence of this ...
Seven infants were factor V Leiden heterozygous and another one homozygous. Methylenetetrahydrofolate reductase genotype was found in 5 infants. Five cases were found to be double heterozygous for those two mutations, and another one double heterozygous for FVL and factor II. The results of this ...
025。观察组和对照组均未检出FactorVLeiden突 变。结论 ATIII基因多态性可能与广东籍汉族妇女子痫前期和子痫发病相关,而FactorVLeiden突变与其发病无关。 关键词:子痫前期;子痫;抗凝血酶III;凝血因子V;基因多态性 中图分类号:R711.6 文献标识码:A 文章编号:1672.3619(2011)04.0436.03 ...
Factor V Leiden and factor II c.*97G>A are relatively commonamong the general population and VTE can be fatal. However, prenatal testingand population screening are not indicated due to the low penetrance ofthese variants, later age of onset, and lack of genotype-directedprophylaxis. Testing ...