: a genetic disorder caused by factor V Leiden that is marked by an increased risk of abnormal blood clot formation leading especially to deep vein thrombosis or pulmonary embolism Note: Factor V Leiden is inherited as an autosomal dominant trait requiring that only one parent pass on a copy...
Genetic Testing for Factor V LeidenCPT(R)* Codes83891 Molecular diagnostics; isolation or extraction of highly purified nucleic acid, each nucleic acid type (DNA or RNA)83892 Molecular diagnostics; enzymatic digestion, each enzyme treatment83896 Molecular diagnostics; nucleic acid probe, each83898 ...
Factor V Leiden: A genetic risk factor for thrombotic microangiopathy in patients with normal von Willebrand factor‑cleaving protease activity. Blood 2002;99:437‑42.Raife TJ,Lentz L,Atkinson BS,et al.Factor ⅤLeiden: a genetic risk factor for thrombotic microangipathy in patients with ...
b.The process by which such a change occurs, either through an alteration in the nucleotide sequence coding for a gene or through a change in the physical arrangement of the genetic material. c.The nucleotide sequence, trait, or individual that results from such a change. ...
PATHOGENIC MECHANISMS AND MOLECULAR BASIS Factor V Leiden is a genetic disorder characterized by a poor anticoagulant response to APC. APC is a natural anticoagulant protein that cleaves and inactivates procoagulant Factors Va and VIIIa, thereby downregulating further thrombin generation.5,6 APC in...
Several genetic mutations that cause hereditary disorders predisposing to thrombosis have been described, point mutation in the coagulation factor V gene (FV:R506Q), called factor V Leiden, being the most common of them. A new inexpensive and simple polymerase chain reaction-single-strand ...
Non-PCR-dependent detection of the factor V Leiden mutation from genomic DNA using a homogeneous invader microtiter plate assay. Mol Diagn 1999; 4: 135–144. Article CAS Google Scholar Poort SR, Rosendaal FR, Reitsma PH, Bertina RM . A common genetic variation in the 3′-untranslated ...
Common F5 genetic variation probably contributes to this variability. Patients/methods: APC resistance was determined in 250 FV Leiden heterozygotes and 133 normal relatives using the prothrombinase-based assay, which specifically measures the susceptibility of plasma FVa to APC. The effects of 12 F5...
Purpose: To investigate genetic prothrombotic factors (factor V Leiden and prothrombin gene G20210A mutations) and their relation with retinal vascular occlusions in ocular Behçet disease. Methods: Thirty Behçet patients were prospectively recruited into the study. Their ...
Thrombophilia in Infancy: Factor V Leiden and MTHFR or Factor II Double Heterozygocity as a Risk Factordoi:10.1080/08880010390158847Genetic FactorsInfantsNewbornsThrombophiliaThrombophilic risk factors are associated with thromboembolism in children but data in infants and neonates are not well established. ...