GENETEST REVIEW Genetics in Medicine Factor V Leiden thrombophilia Jody Lynn Kujovich, MD TABLE OF CONTENTS Pathogenic mechanisms and molecular basis ...2 Prevalence...2 Diagnosis...
Factor V Leiden (FVL) is the name of a specific gene mutation which leads to a hypercoagulability state with serious clinical consequences [5]. Less than two decades of its discovery, the pathophysiol- ogy, clinical consequences, and therapeutic management of the thrombophilic state associated to...
In the past few years, a lot of attention has been paid to genetic predisposition to thrombophilia—for example factor V Leiden, prothrombin gene mutations, and deficiencies in protein C, protein S, antithrombin, etc. [5]. Factor V Leiden (FVL) is a genetic variant of normal factor V. As...
9 RegisterLog in Sign up with one click: Facebook Twitter Google Share on Facebook factor VIII Thesaurus Medical Legal Financial Acronyms Encyclopedia Wikipedia Related to factor VIII:Factor VIII deficiency factor VIII n. A protein substance in blood plasma that is an essential part of the blood...
The Association of Factor V Leiden and Prothrombin Gene Mutation and Placenta-Mediated Pregnancy Complications: A Systematic Review and Meta-analysis of Pr... Background: Factor V Leiden (FVL) and prothrombin gene mutation (PGM) are common inherited thrombophilias. Retrospective studies variably ...
Factor V Leiden and prothrombin gene G20210A mutation and in vitro fertilization: prospective cohort study The influence of thrombophilia on fertility and on IVF outcome is very controversial. The objectives of this study were: (i) to compare the prevalence of F... G Ricci,P Bogatti,L Fische...
摘要: Spontaneous coronary artery dissection is a rare but increasingly recognized cause of acute myocardial ischemia in young adults, especially in women. We report a case of spontaneous coronary dissection in a young healthy man who was also a carrier of the factor V Leiden gene mutation....
凝血因子Factor V是一种凝血过程中的蛋白因子,它位于内外源性凝血途径的交汇点,能够加速和促进凝血酶原的激活和凝血酶的生成。Factor V基因上的鸟嘌呤G突变为腺嘌呤A,造成第506上的谷氨酰胺被精氨酸替代,这样就形成了突变基因Factor V Leiden(FVL)。FVL会使凝血酶蛋白C(APC)的活性作用遭到抵抗,从而使血液的凝血功...
The Association of Factor V Leiden and Prothrombin Gene Mutation and Placenta-Mediated Pregnancy Complications: A Systematic Review and Meta-analysis of Pr... The association of factor V leiden and prothrombin gene mutation and placenta-mediated pregnancy complications: a systematic review and meta-anal...
The prevalence of the Leiden mutation was tested in 50 mothers of premature infants and in 56 mothers of intrauterine-growth-retarded neonates. The prevale... E Erhardt,J Stankovics,D Molnár,... - 《Biology of the Neonate》 被引量: 56发表: 2000年 Factor V Leiden and Prothrombin Gene 202...