There are patients with factor XI deficiency of 25-30% who bleed spontaneously or while undergoing surgery. The amount of factor XI needed to prevent a bleeding episode in a patient prone to bleeding is not known.Aledort,L.M.Hematology and Medical Oncology...
Two disease phenotypes have been recognized forfactor I deficiency. The first phenotype described, marked susceptibility to infections, relates to the role of factor I as a cofactor for C3bBb dissociation. When factor I is lacking, C3bBb continues to cleave C3 unabated, and a secondary deficit ...
Molecular analysis has been performed on a Malaysian patient with a severe bleeding disorder due to factor XIII A subunit deficiency. Total mRNA was isola... S Aslam,VC Yee,S Narayanan,... - 《British Journal of Haematology》 被引量: 47发表: 1997年 Substitution of Factor XIII: A Therapeuti...
The choice of treatment for patients with factor VII deficiency depends on the site and severity of bleeding and the baseline factor VII activity. Therapeutic options for major bleeds include recombinant activated factor VIIa (rFVIIa), plasma-derived factor VII, fresh frozen plasma, and prothrombin ...
To date several clinical trials have been conducted to test IGF-1 under several conditions and an infinity of animal models have been used to investigate its deficiency, treatment and to exploit its actions. Phase I studies from the late 1980s using IGF-1 to treat Laron’s Syndrome (GH ins...
Combined factor V and factor VIII deficiency is an extremely rare bleeding disorder for which research is lacking. We present the case of a 33-year-old man requiring repeat mitral valve replacement. A multidisciplinary team approach was utilized to minimize his risk of bleeding which included the...
Hyper-responsiveness to DDAVP for patients with type I von Willebrand's disease and normal intra-platelet von Willebrand factor. Desmopressin (DDAVP) has gained wide acceptance as the drug of first choice in the treatment or prevention of haemorrhages in the majority of patients with... F Rode...
The factor deficiency might have aggravated the haemorrhagic diathesis in the boy. The retinal haemorrhages in the boy resolved spontaneously without treatment to correct the coagulation abnormality. Individuals with more severe factor VII deficiency may require replacement with plasma or prothrombin complex...
IGF-I is a closely regulated hormone. Consequently, its logical therapeutical applications seems to be limited to restore physiological circulating levels in order to recover the clinical consequences of IGF-I deficiency, conditions where, despite continuous discrepancies, IGF-I treatment has never been...
Santagostino, E., Gringeri, A., and Mannucci, P. M. 1999. Home treatment with recombinant activated factor VII in patients with factor VIII inhibitors: the advantages of early intervention. Br. J. Haematol. 104:22–26. ArticlePubMedCASGoogle Scholar ...