In factor XI deficiency, however, the phenotype does not in any way follow the laboratory level of the factor. For example, there are many people with no factor XI who do not bleed excessively, either spontaneously or while undergoing surgical intervention. There are patients with factor XI ...
In factor II deficiency due to liver disease, vitamin K deficiency, or vitamin K antagonist use, assays of other clotting factors reveal a decrease in the level of all vitamin K–dependent factors (ie, factor II, factor VII, factor IX, factor X, protein C) Treatment & Management What ...
The choice of treatment for patients with factor VII deficiency depends on the site and severity of bleeding and the baseline factor VII activity. Therapeutic options for major bleeds include recombinant activated factor VIIa (rFVIIa), plasma-derived factor VII, fresh frozen plasma, and prothrombin ...
Molecular analysis has been performed on a Malaysian patient with a severe bleeding disorder due to factor XIII A subunit deficiency. Total mRNA was isola... S Aslam,VC Yee,S Narayanan,... - 《British Journal of Haematology》 被引量: 47发表: 1997年 Substitution of Factor XIII: A Therapeuti...
Hereditary factor XII (FXII) deficiency is a clinically asymptomatic, autosomal recessive disorder. We have experienced a rare case of FXII deficiency in a... Eri,Matsuki,Yoshitaka,... - 《Blood Coagulation & Fibrinolysis An International Journal in Haemostasis & Thrombosis》 被引量: 4发表: 201...
The factor deficiency might have aggravated the haemorrhagic diathesis in the boy. The retinal haemorrhages in the boy resolved spontaneously without treatment to correct the coagulation abnormality. Individuals with more severe factor VII deficiency may require replacement with plasma or prothrombin complex...
Contact activation refers to the process of surface-induced activation of factor XII (FXII), which initiates blood coagulation and is captured by the activated partial thromboplastin time (aPTT) assay. Here, we show the mechanism and diagnostic implications of FXII contact activation. Screening of ...
The prevalence of ICH is highly variable among congenital bleeding disorders, with the highest incidence observed in factor (F) XIII deficiency (FXIIID) (30%). This life-threatening presentation is less common in afibrinogenemia, FVIII, FIX, FVII, and FX deficiencies, and is rare in severe ...
Thus, patients with severe FXIII deficiency (FXIIID) present with delayed wound healing, recurrent spontaneous miscarriage, and umbilical cord bleeding as well as intracranial hemorrhage (ICH) [6]. While FXIIID can be acquired, congenital FXIIID is extremely rare. Severely affected patients ...
These data suggest that, at least in the angiotensin II infusion-induced AAA mouse model, the role of VWF in AAA pathophysiology is limited.Similar content being viewed by others Deficiency of peroxiredoxin 2 exacerbates angiotensin II-induced abdominal aortic aneurysm Article Open access 14 ...