There are patients with factor XI deficiency of 25-30% who bleed spontaneously or while undergoing surgery. The amount of factor XI needed to prevent a bleeding episode in a patient prone to bleeding is not known.Aledort,L.M.Hematology and Medical Oncology...
The choice of treatment for patients with factor VII deficiency depends on the site and severity of bleeding and the baseline factor VII activity. Therapeutic options for major bleeds include recombinant activated factor VIIa (rFVIIa), plasma-derived factor VII, fresh frozen plasma, and prothrombin ...
Molecular analysis has been performed on a Malaysian patient with a severe bleeding disorder due to factor XIII A subunit deficiency. Total mRNA was isola... S Aslam,VC Yee,S Narayanan,... - 《British Journal of Haematology》 被引量: 47发表: 1997年 Substitution of Factor XIII: A Therapeuti...
Our results demonstrated that Nrf2 deficiency promoted Th17 differentiation and function during LN development. Moreover, our results suggested that the regulation of Th17 differentiation via NRF2 could be a therapeutic target for the treatment of subclinical LN patients. 展开 ...
0.0159.eKLF2expression in human peripheral blood mononuclear cells (PBMC) from lean and obese patients,n = 10 biologically independent human subjects,p = 0.0068fWT BMDMKlf2expression after acute treatment with palmitic acid (PA),n = 5 biologically independent mice,p = 0.0079...
A serious complication of current protein replacement therapy for hemophilia A patients with coagulation factor VIII (FVIII) deficiency is the frequent dev... M Moayeri,T Hawley,R Hawley - 《Molecular Therapy》 被引量: 228发表: 2005年 Kinetic expression of endothelial adhesion molecules and relation...
Since both transcriptional regulation and autophagic function are important in supporting neuronal function, we hypothesized that NRBF2 deficiency may lead to cognitive deficits. To test this, we developed a new mouse model with nervous system-specific knockout of Nrbf2. In a series of behavioral ...
One of 2 additional patients with partial hematologic responses had improvement in factor X. Thus, aggressive treatment of the underlying plasma cell dyscrasia in AL amyloidosis can lead to the amelioration of amyloid-related factor X deficiency....
The factor deficiency might have aggravated the haemorrhagic diathesis in the boy. The retinal haemorrhages in the boy resolved spontaneously without treatment to correct the coagulation abnormality. Individuals with more severe factor VII deficiency may require replacement with plasma or prothrombin complex...
Fas deficiency in mice inhibits chondrocyte apoptosis and cartilage destruction. Next, we examined the functional relevance of HIF-2a-mediated Fas upregulation in chondrocyte apoptosis and the functional consequence of chondrocyte apoptosis in OA pathogenesis in vivo. To do this, we used the C57BL/6...