In factor XI deficiency, however, the phenotype does not in any way follow the laboratory level of the factor. For example, there are many people with no factor XI who do not bleed excessively, either spontaneously or while undergoing surgical intervention. There are patients with factor XI ...
The choice of treatment for patients with factor VII deficiency depends on the site and severity of bleeding and the baseline factor VII activity. Therapeutic options for major bleeds include recombinant activated factor VIIa (rFVIIa), plasma-derived factor VII, fresh frozen plasma, and prothrombin ...
Molecular analysis has been performed on a Malaysian patient with a severe bleeding disorder due to factor XIII A subunit deficiency. Total mRNA was isola... S Aslam,VC Yee,S Narayanan,... - 《British Journal of Haematology》 被引量: 47发表: 1997年 Substitution of Factor XIII: A Therapeuti...
In the presence of Ca2+, factor XIa catalyzes the hydrolysis of a peptide bond in factor IX, releasing a 10-kDa glycopeptide and activating factor IX into IXa. Factor IX is a glycoprotein encoded by a chromosome X gen. Its deficiency produces hemophilia B, characterized by severe c...
One of 2 additional patients with partial hematologic responses had improvement in factor X. Thus, aggressive treatment of the underlying plasma cell dyscrasia in AL amyloidosis can lead to the amelioration of amyloid-related factor X deficiency....
The factor deficiency might have aggravated the haemorrhagic diathesis in the boy. The retinal haemorrhages in the boy resolved spontaneously without treatment to correct the coagulation abnormality. Individuals with more severe factor VII deficiency may require replacement with plasma or prothrombin complex...
Recurrent implantation failure (RIF) caused by various etiological factors remains a challenge for fertility clinicians using assisted reproductive technology (ART) worldwide. Dysregulation of leukemia inhibitory factor (LIF) in the endometria of women w
In addition, Factor VIII is an acute phase protein and so its levels will increase in response to stress including pregnancy and surgery. This can lead to shortening of the APTT and in some cases may mask an otherwise prolonged APTT due to another clotting factor deficiency e.g. Factor XI....
2007 the American Association of Clinical Endocrinologist argued that there are insufficient data on both efficacy and safety of long-term use of growth hormone in short children who do not have growth hormone deficiency. The AACE concludes that any treatment ought to be carefully and individually ...
FXII-, FXI-, FVIII-, FIX-, and PK-deficient plasmas from individuals with congenital factor deficiency were obtained from George King Bio-medical and had no detectable antigen level by western blotting and did not exhibit coagulant activity for each respective protein. FXII-deficient plasma ...