One of the two archetypal pathways of caspase activation, known also as "the death receptor pathway." This pathway of programmed cell death is initiated through the stimulation of the transmembrane...Springer Berlin HeidelbergEncyclopedia of Cancer...
Apoptosis is known as a physiological process of cell deletion and is also a process of programmed cell death, resulting in morphological change and DNA fragmentation. It is stimulated by external or internal events of cells, one of which is the extrinsic pathway mediated by the death receptor. ...
Furthermore, MMV560185 was found to specifically induce an extrinsic pathway of apoptosis in the parasitized cell. 2. Materials and methods 2.1. Chemicals Culture media RPMI-1640, Penicillin-Streptomycin, Dulbecco's Modified Eagle's Medium (DMEM), were purchased from Gibco, life technologies. Fetal...
Altered regulation of extrinsic apoptosis pathway in HCV-infected HCC cells enhances susceptibility to mapatumumab-induced apoptosis 喜欢 0 阅读量: 34 作者: X Zhang,AC Frank,CM Gille,M Daucher,J Kabat,S Becker,RA Lempicki,KJ Cortez,MA Polis,GM Subramanian 展开 摘要: Background: ...
Purpose: Targeting the protein neddylation pathway has become an attractive anticancer strategy; however, the role of death receptor–mediated extrinsic apoptosis during treatment remained to be determined.Experimental Design: The activation of extrinsic apoptosis and its role in MLN4924 treatment of human...
Selective Role of Intracellular Chloride in the Regulation of the Intrinsic but Not Extrinsic Pathway of Apoptosis in Jurkat T-cells Apoptosis is a genetic program for the removal of unwanted cells from an organism, which is distinct from necrosis by its characteristic volume loss or apo... G ...
The second pathway, which is also referred to as the‘intrinsic’pathway, is controlled by members of the Bcl-2 family. A long—stand 二条主要路为apoptosis启蒙存在。 一条路,也被命名`外在’路,由死亡感受器官, TNF感受器官的小群斡旋superfamily。 第二条路,也指`内在’路,由Bcl-2家庭的成员控制...
The characterisation of intrinsic apoptosis in nematode, fly and vertebrates makes it the best known among animals3,12,13. Even if recent research suggests divergences between intrinsic apoptosis14, this pathway share the specificity to be initiated by a caspase with a pro-domain CARD activated by...
As we know now, the proteins triggering the extrinsic cell- death pathway are ligands of the tumor necrosis factor (TNF) family, acting mainly in the form of type II membrane proteins anchored to cells of the immune system. Originally, however, these proteins were identified in the sera of ...
Death receptors are cell-surface cytokine receptors belonging to the tumor necrosis factor/nerve growth factor (TNF/NGF) receptor superfamily that trigger apoptosis after binding a group of structurally related ligands or specific antibodies (1–3). The