Expression quantitative trait methylation (eQTM) analysis identifies DNA CpG sites at which methylation is associated with gene expression. The present study describes an eQTM resource of CpG-transcript pairs derived from whole blood DNA methylation and RNA sequencing gene expression data in 2115 ...
Zhang et al.8identified a methylation quantitative trait locus. This mQTL significantly impacted expression of these genes within the genomic region of thealcohol dehydrogenasegenesADH1BandADH1C. Altered expression of ADH1B and ADH1C was in part related to alcohol dependence. ...
Expression quantitative trait locus analysis has emerged as an important component of efforts to understand how genetic polymorphisms influence disease risk and is poised to make contributions to translational medicine. Here we review how expression quantitative trait locus analysis is aiding the identificati...
RESULTS: An association between rs16906252C>T and increased risk of developing MGMT-methylated colorectal cancer in the Sydney sample was observed [OR, 3.3; 95% confidence interval (CI), 2.0-5.3; P T represents an expression and methylation quantitative trait locus. CONCLUSIONS: We provide ...
Here, we analyze 275 normal colon and 276 colorectal cancer samples from the SYSCOL cohort, discovering 10,231 and 5,199 TE-expression quantitative trait loci (eQTLs) in normal and tumor tissues, respectively, of which 376 are colorectal cancer specific eQTLs, likely due to methylation changes....
This enables the study of tissue-specific gene expression and the identification of genetic associations with gene expression levels (expression quantitative trait loci, or eQTLs) across many tissues, including both local (cis-eQTLs) and distal (trans-eQTLs) effects. In this study, we associate ...
PP153 Characterizing the relationship between DNA-methylation quantitative trait loci (mQTL), expression quantitative trait loci (eQTL), and breast cancer ... PJ Ho,J Li - 《Esmo Open》 被引量: 0发表: 2023年 Doubled Haploid Platform: An Accelerated Breeding Approach for Crop Improvement Haploid...
Gene expression genetic studies in human tissues and cells identify cis- and trans-acting expression quantitative trait loci (eQTLs). These eQTLs provide insights into regulatory mechanisms underlying disease risk. However, few studies systematically cha
Expression quantitative trait loci for ETV4 and MEOX1 are associated with adult asthma in Japanese populations Article Open access 22 September 2021 Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis Article Open access 20 January 2020 A ...
In addition, an expression quantitative trait loci (eQTL) analysis using RNA-sequencing data from thyroid tissue for the identified loci has not been conducted in patients with thyroid cancer. Therefore, we conducted both GWAS and eQTL studies to identify potential susceptibility loci for thyroid ...