5-azacytidine Experiments Provide Early Clues to the Role of Methylation in Gene Expression Prior to 1980, there were a number of clues that suggested that methylation might play a role in the regulation of gene expression. For example, J. D. McGhee and G. D. Ginder compared the methylatio...
Epigenetic is the study of those alterations regulating gene expression without altering DNA sequence and inherited by transmission through cell division. ... Laura,Lattanzio,Cristiana,... - 《World Journal of Translational Medicine》 被引量: 4发表: 2015年 The role of DNA methylation in cancer gen...
Owing to the well-characterized physiological properties ofL. paracaseiZhang18and the availability of thepglXmutant, it was selected from the isolate set as a representative strain for further probing the potential role of 6mA methylation in carbohydrate metabolism. Although not drastic, an obvious gr...
To verify the inhibitory role of methylation in GFAP expression, we incubated E11.5 neuroepithelial cells, which do not normally express GFAP in response to LIF (see Figure 1), with LIF in the presence or absence of a demethylating agent, 5-aza-2′-deoxycytidine (5-aza-CdR). As shown ...
63 controls, indicating that the frequency of this putative mutation is <1% in Italy. Since the Italian population usually shows allelic frequencies similar to the other Caucasian populations, we suggest that the T54A allele might play a role in infertility only in Taiwanese or Asiatic individuals...
No study has attempted to define the role of global regulation of acetylation and 2-hydroxyisobutyrylation in the energy conversion mechanism of G. lamblia when sugar, the main source of energy, is in short supply (40, 41). Interestingly, when the G. lamblia experienced the stress of sugar...
In addition, the role of cytosine methylation of the promoter region has been analyzed to elucidate whether this epigenetic mechanism might contribute to control the specific regulation of the expression of this gene. Results Features of the 5' flanking region of the human podocalyxin The human ...
(TME), herein defined to be composed of heterogeneous andinteractive populations of cancer cells and cancer stem cellsalong with a multiplicity of recruited stromal cell types—thetransformed parenchyma and the associated stroma—is nowwidely appreciated to play an integral role in tumorigenesisand ...
International Journal of Molecular Sciences Article The Role of Genetic Polymorphisms as Related to One-Carbon Metabolism, Vitamin B6, and Gene–Nutrient Interactions in Maintaining Genomic Stability and Cell Viability in Chinese Breast Cancer Patients Xiayu Wu 1, Weijiang Xu 1, Tao Zhou 1, Neng ...
Full-term pregnancy at an early age confers long-term protection against breast cancer. Published data shows a specific transcriptomic profile controlling chromatin remodeling that could play a relevant role in the pregnancy-induced protection. This process of chromatin remodeling, induced by the breast...