(2016). DNA methylation profiling reveals correlation of differential methylation patterns with gene expression in human epilepsy. J. Mol. Neurosci. 59, 68-77. doi: 10.1007/s12031-016-0735-6Wang, L.; Fu, X.W.; Peng, X.; Xiao, Z.; Li, Z.G.; Chen, G.J.; Wang, X.F. DNA ...
genomic regions, and genes. We develop a model that predicts gene expression based on DNA methylation (R2 = 0.2).Post hocanalysis of this model confirms prior relationships, and identifies novel relationships between methylation and gene expression. Additionally...
The impact of methylome changes on gene expression and thereby on the function of the tissue, including establishing receptivity to implanting embryo, is also unclear. Therefore, this study used genome-wide technologies to characterize the methylome and the correlation between DNA methylation and gene ...
Matched methylation and gene expression data from The Cancer Genome Atlas were plotted to illustrate the correlation for selected cancer testis antigens (CTAs): (A) MAGEA1, (B) PAGE2, (C) CT83, and (D) SMC1B. The x axes give the β value of the region of the CTA 200 bp upstream ...
A large body of evidence demonstrates that DNA methylation plays a role in gene regulation in animal cells. Not only is there a correlation between gene transcription and undermethylation, but also transfection experiments clearly show that the presence of methyl moieties inhibits gene expression in ...
methylation contexts among 2 kb proximal promoters, gene bodies, and 2 kb downstream regions were observed among PS, TS, and SS. Further analysis revealed a perceptible global correlation between 5mC methylation levels of gene bodies and transcript levels but failed to reveal a correlation ...
2、基因结果页面,也提供了六个不同的面板:Summary,DMG,Meth-Exp correlation,Survival,FEM (PPI)和FEM (COME)。 Summary:显示了一个基因的基本信息,紧接着是DEG的箱线图和位于该基因内的CpG表。 DMG:提供了DMG的箱线图。 Meth-Exp correlation:提供了基因表达与基因启动子甲基化水平之间的Pearson和Spearman相关...
African Americans (AAs) are an admixed population with widely varying proportion of West African ancestry (WAA). Here we report the correlation of WAA to gene expression and DNA methylation in AA-derived hepatocytes, a cell type important in disease and
There are, however, some genes where there is no apparent correlation between levels of methylation and gene expression, and even a small class where gene activation is correlated with increased methylation of the DNA. I propose a unifying hypothesis to explain these apparently divergent cases: ...
Brief Introduction: Contains DNA methylation, gene expression, correlation of DNA methylation and gene expression in paired samples, and clinicopathological conditions gathered from the GEO and TCGA. Pubmeth Application: Cancer-related database Brief Introduction: Collects and collates cancer-related methylat...