Stem cell derived exosomes-based therapy for acute lung injury and acute respiratory distress syndrome: A novel therapeutic strategyAcute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a common critical disease which can be caused by multiple pathological factors in clinic. However, ...
Limited spontaneous recovery of function as a result of brain remodelling after stroke or injury does occur, and cell-based therapies have been used to promote these endogenous processes. Increasing evidence is demonstrating that the positive effects of such cell-based therapy are mediated by exosomes...
Cardiovascular disease is a significant cause of morbidity and mortality around the world. The damaged cardiac tissue is unable to repair itself following injury warranting the development of alternate therapies. Cell therapy has emerged recently as a viable treatment option resulting in significant improv...
Stem cells are a category of cells that can self-renew and differentiate into various cell types. They are involved in a wide range of physiological and pathological processes including healing of wound, tissue regeneration and tumor formation [1]. Lately, concerns have emerged regarding the safety...
Although stem cell-based therapy has demonstrated considerable potential to manage certain diseases more successfully than conventional surgery, it nevertheless comes with inescapable drawbacks that might limit its clinical translation. Compared to stem
cornea-on-a-chip to establish an in vitro mild corneal injury model to study whether cell-free therapy promotes corneal wound healing. they found that the bone marrow-derived mesenchymal stem cells exosomes could significantly p...
Exosomes derived from mesenchymal stem cells primed with disease-condition-serum improved therapeutic efficacy in a mouse rheumatoid arthritis model via enhanced TGF-β1 production Eun Wha Choi, I.-Rang Lim, Ji Hong Park, Jiwoo Song, Bongkum Choi & Sungjoo Kim Stem Cell Research & Therapy vol...
cell therapymyocardial infarctionstem cellFinding effective treatments for cardiac diseases is among the hottest subjects in medicine; cell-based therapies have brought great promises for managing a broad range of life-threatening heart complications such as myocardial infarction. After clarifying the ...
Nucleic acid delivery A major challenge for all gene therapy techniques is the distribution of recombinant DNA to target cells. Exosomes have recently been proposed as a natural means of precisely delivering medications and biological materials to target cells [167]. A previous study confirmed that ...
Here, we report a noninvasive and repeatable method for exosome delivery through inhalation after myocardial infarction (MI), which we called stem cell–derived exosome nebulization therapy (SCENT).#Stem cell–derived exosomes were characterized for size distribution and surface markers. C57BL/6 mice...