Exosomes are essential paracrine mediators, which can participate in cell communication through substance transmission. In this regard, this review mainly discusses the current research progress of neural stem cell-derived exosomes. This paper mainly introduces the self-regulation of neural stem cells (...
近日,来自南方医科大学中西医结合医院神经外科的陈陆馗教授等学者在BIOCELL期刊发表了题为“Neural stem cell-derived exosomes: a cell-free transplant for potential cure of neurological diseases”的综述文章,收录于特刊 Exosomes in Cell Communication and Disease: From Biomarkers to Therapeutic Targets中。文章主要...
然而临床批准的治疗肝纤维化的药物依然十分有限,临床治疗肝纤维化的药物亟需进一步探索和开发。研究表明,脂肪间充质干细胞(Adipose-derived stromal cells,ADSC)具有组织修复能力和免疫调节能力,在肝损伤疾病中显示出优异的治疗潜力。但ADSC...
近日,研究人员评估了HucMSC-Ex治疗创伤性胰腺炎的效果。相关研究结果发表在Stem Cell Research & Therapy上。 研究人员通过超速离心法获得HucMSC-Ex,并使用透射电镜和Western blot分析进行鉴定。随后他们采用控制压力的方法构建了不同程度...
1. Neural stem cell-derived exosomes: a cell-free transplant for potential cure of neurological diseases 神经干细胞来源的外泌体:一种用于神经系统疾病潜在治疗的无细胞移植方法 JIAJUN HUANG, WEI WANG, WENTONG LIN, HENGSEN CAI, ZHIHAN ZHU, WAQAS AHMED, QIANKUN ZHANG, JIALE LIU, YIFAN ZHANG, RONG...
stem cell-derived exosomes as a therapeutic strategy for cardiac diseases. We discuss the molecular mechanisms underlying their cardioprotective effects, summarize preclinical and clinical studies investigating their efficacy, and address the challenges and future perspectives of exosome-based therapies. The ...
近日,昆明理工大学司维教授团队在Stem Cell Research & Therapy杂志发表题为“Perinatal tissue-derived exosomes ameliorate colitis in mice by regulating the Foxp3 + Treg cells and gut microbiota”的研究论文(2023 Mar 20;14(1):43)。 团队将人脐带和胎盘两种围产组织MSC来源的外泌体(hUC-Exos和hFP-Exos)...
Stem cell-derived exosomes exert comparable therapeutic effects to those of their parental stem cells without causing immunogenic, tumorigenic, and ethical disadvantages. Their therapeutic advantages are manifested in the management of a broad spectrum o
Numerous studies over the past few decades have evaluated the therapeutic potential of exosomes in the treatment of various neurological diseases. In this review, after recalling the features and therapeutic history, we will discuss the latest stem cell-derived exosome-based therapies for these ...
Exosomes derived from stem cells of human deciduous exfoliated teeth inhibit angiogenesis in vivo and in vitro via the transfer of miR-100-5p and miR-1246. Background: Anti-angiogenic therapy has been shown to be a ...