However, due to storage limitations and because cell senescence occurs during in vitro expansion, their clinical application is challenging. Exosomes, which are secreted by MSCs through paracrine signalling, not only have the same effects as MSCs, but they also have the advantages of targeted ...
Mesenchymal stem cell-derived exosomes (MSCs-Exos) have demonstrated comparable efficacy to MSCs in the treatment of diabetes and its associated complications [8]. MSCs-Exos have shown a superior therapeutic and regenerative effect in treating DM compared with the original cells in some research ...
ReviewPaper27 May 2025 From Cells to Exosomes: a Review of Non-Surgical Biotherapeutic-Based Strategies for Liver Regeneration in the Face of End-Stage Diseases Fatemeh Askari Yazdian Matin Mojaveri Samak Elham Vojoudi ReviewPaper24 May 2025 ...
extracellular vesicles andexosomesin particular are increasingly being implicated as key mediators of cell-cell communication (Jing et al., 2018). It has been demonstrated that active Wnt signalling can be induced through exosomal transport ofWnt proteins(Gross et al., 2012), and also that that ...
Organoids, exosomes, and cell extracts from a wide variety of stem cells are actively studied for in vitro and in vivo applications. ▪ Stem cells exhibit normal growth control, but cancer stem cells represent the uncontrolled growth of mutant cells that can have a negative effect in the bod...
Stem Cell Research & Therapy Home About Articles Submission Guidelines Submit manuscript Review Open access Published: 18 July 2024 Exosomes repairment for sciatic nerve injury: a cell-free therapy Guang-Da Xin, Xue-Yan Liu, Xiao-Di Fan & Guan-Jie Zhao Stem Cell Research & Therapy volume ...
Mesenchymal stromal cell-derived exosomes in cardiac regeneration and repair. Stem Cell Reports. 2021;16(7):1662–73. Article CAS PubMed PubMed Central Google Scholar Tang Y, Zhou Y, Li HJ. Advances in mesenchymal stem cell exosomes: a review. Stem Cell Res Ther. 2021;12(1):71. ...
In addition, the advent of induced PSC (iPSC) technology is enabling the development of a wide range of cell-based disease models from genetically predisposed patients, thereby facilitating drug discovery. In this Review, we discuss the recent progress and remaining challenges for the use of PSCs...
Mesenchymal stem cells (MSCs) have captured great attention in regenerative medicine for over a few decades by virtue of their differentiation capacity, potent immunomodulatory properties, and their ability to be favorably cultured and manipulated. Recen
Cell proliferation assay The proliferation of BMECs stimulated by exosomes was measured by using a Cell Counting Kit-8 (CCK-8; Elabscience). Briefly, after stimulation with hydrocortisone and treatment with exosomes, 5000 cells/well were incubated in 96-well dishes for 24 h. Then, 10-mL CCK-...